Bubbles and HIFU: the good, the bad, and the ugly
Rapid hyperthermia resulting in tissue necrosis has proven to be a useful therapeutic modality for clinical application of high-intensity focused ultrasound. At therapeutic intensities, the hyperthermia is often accompanied by bubble activity. In vitro and in vivo experiments alike have shown that u...
| Main Authors: | , , , |
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| Format: | Conference item |
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American Institute of Physics
2002
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| _version_ | 1797096473922371584 |
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| author | Holt, G Roy, R Edson, P Yang, X |
| author_facet | Holt, G Roy, R Edson, P Yang, X |
| author_sort | Holt, G |
| collection | OXFORD |
| description | Rapid hyperthermia resulting in tissue necrosis has proven to be a useful therapeutic modality for clinical application of high-intensity focused ultrasound. At therapeutic intensities, the hyperthermia is often accompanied by bubble activity. In vitro and in vivo experiments alike have shown that under certain conditions bubble activity can give rise to a doubling of the heating rate. With a view towards harnessing the energy-concentrating effects of bubbles to do useful clinical work, we report the results of experiments and modeling for the dynamic and thermal behavior of bubbles subjected to 1-megahertz ultrasound at megapascal pressures. The dominant heating mechanism depends on bubble size, medium shear viscosity number and frequency-dependent acoustic attenuation. The bubble size distribution, in turn, depends on insonation control parameters (acoustic pressure, pulse duration), medium properties (notably dissolved gas concentration) and bubble-destroying shape instabilities. The evidence obtained so far points to a range of control parameters for which bubble-enhanced heating can be assured. [Work supported by DARPA and the U.S. Army] |
| first_indexed | 2024-03-07T04:42:21Z |
| format | Conference item |
| id | oxford-uuid:d215d037-82d4-4ee7-90e4-1fb4853ac7e3 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:42:21Z |
| publishDate | 2002 |
| publisher | American Institute of Physics |
| record_format | dspace |
| spelling | oxford-uuid:d215d037-82d4-4ee7-90e4-1fb4853ac7e32022-03-27T08:01:23ZBubbles and HIFU: the good, the bad, and the uglyConference itemhttp://purl.org/coar/resource_type/c_5794uuid:d215d037-82d4-4ee7-90e4-1fb4853ac7e3Symplectic Elements at OxfordAmerican Institute of Physics2002Holt, GRoy, REdson, PYang, XRapid hyperthermia resulting in tissue necrosis has proven to be a useful therapeutic modality for clinical application of high-intensity focused ultrasound. At therapeutic intensities, the hyperthermia is often accompanied by bubble activity. In vitro and in vivo experiments alike have shown that under certain conditions bubble activity can give rise to a doubling of the heating rate. With a view towards harnessing the energy-concentrating effects of bubbles to do useful clinical work, we report the results of experiments and modeling for the dynamic and thermal behavior of bubbles subjected to 1-megahertz ultrasound at megapascal pressures. The dominant heating mechanism depends on bubble size, medium shear viscosity number and frequency-dependent acoustic attenuation. The bubble size distribution, in turn, depends on insonation control parameters (acoustic pressure, pulse duration), medium properties (notably dissolved gas concentration) and bubble-destroying shape instabilities. The evidence obtained so far points to a range of control parameters for which bubble-enhanced heating can be assured. [Work supported by DARPA and the U.S. Army] |
| spellingShingle | Holt, G Roy, R Edson, P Yang, X Bubbles and HIFU: the good, the bad, and the ugly |
| title | Bubbles and HIFU: the good, the bad, and the ugly |
| title_full | Bubbles and HIFU: the good, the bad, and the ugly |
| title_fullStr | Bubbles and HIFU: the good, the bad, and the ugly |
| title_full_unstemmed | Bubbles and HIFU: the good, the bad, and the ugly |
| title_short | Bubbles and HIFU: the good, the bad, and the ugly |
| title_sort | bubbles and hifu the good the bad and the ugly |
| work_keys_str_mv | AT holtg bubblesandhifuthegoodthebadandtheugly AT royr bubblesandhifuthegoodthebadandtheugly AT edsonp bubblesandhifuthegoodthebadandtheugly AT yangx bubblesandhifuthegoodthebadandtheugly |