A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom
<br><strong>Background: </strong>Cardiometabolic benefits of the Mediterranean diet have been recognized, but underlying mechanisms are not fully understood.</br> <br><strong>Objectives: </strong>We aimed to investigate how the Mediterranean diet could infl...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2019
|
| _version_ | 1797096474945781760 |
|---|---|
| author | Tong, TYN Wareham, NJ Griffin, JL Koulman, A Forouhi, NG Imamura, F |
| author_facet | Tong, TYN Wareham, NJ Griffin, JL Koulman, A Forouhi, NG Imamura, F |
| author_sort | Tong, TYN |
| collection | OXFORD |
| description | <br><strong>Background: </strong>Cardiometabolic benefits of the Mediterranean diet have been recognized, but underlying mechanisms are not fully understood.</br>
<br><strong>Objectives: </strong>We aimed to investigate how the Mediterranean diet could influence circulating metabolites and how the metabolites could mediate the associations of the diet with cardiometabolic risk factors.</br>
<br><strong>Methods: </strong>Among 10,806 participants (58.9% women, mean age = 48.4 y) in the Fenland Study (2004–2015) in the United Kingdom, we assessed dietary consumption with FFQs and conducted a targeted metabolomics assay for 175 plasma metabolites (acylcarnitines, amines, sphingolipids, and phospholipids). We examined cross-sectional associations of the Mediterranean diet score (MDS) and its major components with each metabolite, modeling multivariable-adjusted linear regression. We used the regression estimates to summarize metabolites associated with the MDS into a metabolite score as a marker of the diet. Subsequently, we assessed how much metabolite subclasses and the metabolite score would mediate the associations of the MDS with circulating lipids, homeostasis model assessment of insulin resistance (HOMA-IR), and other metabolic factors by comparing regression estimates upon adjustment for the metabolites.</br>
<br><strong>Results: </strong>Sixty-six metabolites were significantly associated with the MDS (P ≤ 0.003, corrected for false discovery rate) (Spearman correlations, r: −0.28 to +0.28). The metabolite score was moderately correlated with the MDS (r = 0.43). Of MDS components, consumption of nuts, cereals, and meats contributed to variations in acylcarnitines; fruits, to amino acids and amines; and fish, to phospholipids. The metabolite score was estimated to explain 37.2% of the inverse association of the MDS with HOMA-IR (P for mediation < 0.05). The associations of the MDS with cardiometabolic factors were estimated to be mediated by acylcarnitines, sphingolipids, and phospholipids.</br>
<br><strong>Conclusions: </strong>Multiple metabolites relate to the Mediterranean diet in a healthy general British population and highlight the potential to identify a set of biomarkers for an overall diet. The associations may involve pathways of phospholipid metabolism, carnitine metabolism, and development of insulin resistance and dyslipidemia.</br> |
| first_indexed | 2024-03-07T04:42:22Z |
| format | Journal article |
| id | oxford-uuid:d216be69-7e17-48a9-a755-65792c18e210 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:42:22Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:d216be69-7e17-48a9-a755-65792c18e2102022-03-27T08:01:24ZA combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United KingdomJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d216be69-7e17-48a9-a755-65792c18e210EnglishSymplectic Elements at OxfordOxford University Press2019Tong, TYNWareham, NJGriffin, JLKoulman, AForouhi, NGImamura, F<br><strong>Background: </strong>Cardiometabolic benefits of the Mediterranean diet have been recognized, but underlying mechanisms are not fully understood.</br> <br><strong>Objectives: </strong>We aimed to investigate how the Mediterranean diet could influence circulating metabolites and how the metabolites could mediate the associations of the diet with cardiometabolic risk factors.</br> <br><strong>Methods: </strong>Among 10,806 participants (58.9% women, mean age = 48.4 y) in the Fenland Study (2004–2015) in the United Kingdom, we assessed dietary consumption with FFQs and conducted a targeted metabolomics assay for 175 plasma metabolites (acylcarnitines, amines, sphingolipids, and phospholipids). We examined cross-sectional associations of the Mediterranean diet score (MDS) and its major components with each metabolite, modeling multivariable-adjusted linear regression. We used the regression estimates to summarize metabolites associated with the MDS into a metabolite score as a marker of the diet. Subsequently, we assessed how much metabolite subclasses and the metabolite score would mediate the associations of the MDS with circulating lipids, homeostasis model assessment of insulin resistance (HOMA-IR), and other metabolic factors by comparing regression estimates upon adjustment for the metabolites.</br> <br><strong>Results: </strong>Sixty-six metabolites were significantly associated with the MDS (P ≤ 0.003, corrected for false discovery rate) (Spearman correlations, r: −0.28 to +0.28). The metabolite score was moderately correlated with the MDS (r = 0.43). Of MDS components, consumption of nuts, cereals, and meats contributed to variations in acylcarnitines; fruits, to amino acids and amines; and fish, to phospholipids. The metabolite score was estimated to explain 37.2% of the inverse association of the MDS with HOMA-IR (P for mediation < 0.05). The associations of the MDS with cardiometabolic factors were estimated to be mediated by acylcarnitines, sphingolipids, and phospholipids.</br> <br><strong>Conclusions: </strong>Multiple metabolites relate to the Mediterranean diet in a healthy general British population and highlight the potential to identify a set of biomarkers for an overall diet. The associations may involve pathways of phospholipid metabolism, carnitine metabolism, and development of insulin resistance and dyslipidemia.</br> |
| spellingShingle | Tong, TYN Wareham, NJ Griffin, JL Koulman, A Forouhi, NG Imamura, F A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title | A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title_full | A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title_fullStr | A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title_full_unstemmed | A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title_short | A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom |
| title_sort | combination of metabolites predicts adherence to the mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population the fenland study united kingdom |
| work_keys_str_mv | AT tongtyn acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT warehamnj acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT griffinjl acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT koulmana acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT forouhing acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT imamuraf acombinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT tongtyn combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT warehamnj combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT griffinjl combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT koulmana combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT forouhing combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom AT imamuraf combinationofmetabolitespredictsadherencetothemediterraneandietpatternanditsassociationswithinsulinsensitivityandlipidhomeostasisinthegeneralpopulationthefenlandstudyunitedkingdom |