Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.
BACKGROUND: During the period of 1996-1999, we prospectively monitored 243 Javanese adults and children after arriving in Papua, Indonesia, and microscopically documented each new case of malaria by active surveillance. METHODS: In a randomized, open-label, comparative malaria treatment trial, 72 a...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797096475574927360 |
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| author | Maguire, J Krisin Marwoto, H Richie, T Fryauff, D Baird, J |
| author_facet | Maguire, J Krisin Marwoto, H Richie, T Fryauff, D Baird, J |
| author_sort | Maguire, J |
| collection | OXFORD |
| description | BACKGROUND: During the period of 1996-1999, we prospectively monitored 243 Javanese adults and children after arriving in Papua, Indonesia, and microscopically documented each new case of malaria by active surveillance. METHODS: In a randomized, open-label, comparative malaria treatment trial, 72 adults and 50 children received chloroquine for each incident case of malaria, and 74 adults and 47 children received mefloquine. RESULTS: Among 975 primary treatment courses, the cumulative 28-day curative efficacies were 26% and 82% for chloroquine against Plasmodium falciparum malaria and Plasmodium vivax malaria, respectively. Mefloquine cure rates were far superior (96% against P. falciparum malaria and 99.6% against P. vivax malaria). CONCLUSIONS: Mefloquine is a useful alternative treatment for P. vivax malaria and P. falciparum malaria in areas such as Papua, where chloroquine is still recommended as the first-line therapeutic agent. |
| first_indexed | 2024-03-07T04:42:23Z |
| format | Journal article |
| id | oxford-uuid:d217bb7e-7b3e-4e79-8b41-e385dcad23bb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:42:23Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:d217bb7e-7b3e-4e79-8b41-e385dcad23bb2022-03-27T08:01:22ZMefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d217bb7e-7b3e-4e79-8b41-e385dcad23bbEnglishSymplectic Elements at Oxford2006Maguire, JKrisinMarwoto, HRichie, TFryauff, DBaird, J BACKGROUND: During the period of 1996-1999, we prospectively monitored 243 Javanese adults and children after arriving in Papua, Indonesia, and microscopically documented each new case of malaria by active surveillance. METHODS: In a randomized, open-label, comparative malaria treatment trial, 72 adults and 50 children received chloroquine for each incident case of malaria, and 74 adults and 47 children received mefloquine. RESULTS: Among 975 primary treatment courses, the cumulative 28-day curative efficacies were 26% and 82% for chloroquine against Plasmodium falciparum malaria and Plasmodium vivax malaria, respectively. Mefloquine cure rates were far superior (96% against P. falciparum malaria and 99.6% against P. vivax malaria). CONCLUSIONS: Mefloquine is a useful alternative treatment for P. vivax malaria and P. falciparum malaria in areas such as Papua, where chloroquine is still recommended as the first-line therapeutic agent. |
| spellingShingle | Maguire, J Krisin Marwoto, H Richie, T Fryauff, D Baird, J Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title_full | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title_fullStr | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title_full_unstemmed | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title_short | Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia. |
| title_sort | mefloquine is highly efficacious against chloroquine resistant plasmodium vivax malaria and plasmodium falciparum malaria in papua indonesia |
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