19F-NMR reveals the role of mobile loops in product and inhibitor binding by the São Paolo metallo-β-lactamase

19F-NMR reveals the role of mobile loops in product and inhibitor binding by the São Paolo metallo-β-lactamase

Resistance to β-lactam antibiotics mediated by metallo-β-lactamases (MBLs) is a growing problem. We describe the use of protein-observe 19F-NMR (PrOF NMR) to study the dynamics of the São Paulo MBL (SPM-1) from β-lactam-resistant Pseudomonas aeruginosa. Cysteinyl variants on the α3 and L3 regions, w...

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Dades bibliogràfiques
Autors principals:	Abboud, M, Hinchliffe, P, Brem, J, Macsics, R, Pfeffer, I, Makena, A, Umland, K, Rydzik, A, Li, G, Spencer, J, Claridge, T, Schofield, C
Format:	Journal article
Idioma:	English
Publicat:	Wiley 2017

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