A mechanistic physicochemical model of carbon dioxide transport in blood
A number of mathematical models have been produced that, given the PCO2 and PO2 of blood, will calculate the total concentrations for CO2 and O2 in blood. However, all these models contain at least some empirical features, and thus do not represent all of the underlying physicochemical processes in...
| Main Authors: | , |
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| Format: | Journal article |
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American Physiological Society
2017
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| _version_ | 1797096481471070208 |
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| author | O'Neill, D Robbins, P |
| author_facet | O'Neill, D Robbins, P |
| author_sort | O'Neill, D |
| collection | OXFORD |
| description | A number of mathematical models have been produced that, given the PCO2 and PO2 of blood, will calculate the total concentrations for CO2 and O2 in blood. However, all these models contain at least some empirical features, and thus do not represent all of the underlying physicochemical processes in an entirely mechanistic manner. The aim of this study was to develop a physicochemical model of CO2 carriage by the blood to determine whether our understanding of the physical chemistry of the major chemical components of blood together with their interactions is sufficiently strong to predict the physiological properties of CO2 carriage by whole blood. Standard values are used for the ionic composition of the blood, the plasma albumin concentration and the haemoglobin concentration. All Km values required for the model are taken from the literature. The distribution of bicarbonate, chloride and H+ ions across the red cell membrane follows that of a Gibbs-Donnan equilibrium. The system of equations that results is solved numerically using constraints for mass balance and electro-neutrality. The model reproduces the phenomena associated with CO2 carriage, including the magnitude of the Haldane effect, very well. The structural nature of the model allows various hypothetical scenarios to be explored. Here we examine the effects of: i) removing the ability of haemoglobin to form carbamino compounds; ii) allowing a degree of Cl− binding to deoxygenated haemoglobin; and iii) removing the chloride (Hamburger) shift. The insights gained could not have been obtained from empirical models. |
| first_indexed | 2024-03-07T04:42:28Z |
| format | Journal article |
| id | oxford-uuid:d21d1354-e9f4-4fb9-9cc5-676252caaae5 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:42:28Z |
| publishDate | 2017 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | oxford-uuid:d21d1354-e9f4-4fb9-9cc5-676252caaae52022-03-27T08:01:38ZA mechanistic physicochemical model of carbon dioxide transport in bloodJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d21d1354-e9f4-4fb9-9cc5-676252caaae5Symplectic Elements at OxfordAmerican Physiological Society2017O'Neill, DRobbins, PA number of mathematical models have been produced that, given the PCO2 and PO2 of blood, will calculate the total concentrations for CO2 and O2 in blood. However, all these models contain at least some empirical features, and thus do not represent all of the underlying physicochemical processes in an entirely mechanistic manner. The aim of this study was to develop a physicochemical model of CO2 carriage by the blood to determine whether our understanding of the physical chemistry of the major chemical components of blood together with their interactions is sufficiently strong to predict the physiological properties of CO2 carriage by whole blood. Standard values are used for the ionic composition of the blood, the plasma albumin concentration and the haemoglobin concentration. All Km values required for the model are taken from the literature. The distribution of bicarbonate, chloride and H+ ions across the red cell membrane follows that of a Gibbs-Donnan equilibrium. The system of equations that results is solved numerically using constraints for mass balance and electro-neutrality. The model reproduces the phenomena associated with CO2 carriage, including the magnitude of the Haldane effect, very well. The structural nature of the model allows various hypothetical scenarios to be explored. Here we examine the effects of: i) removing the ability of haemoglobin to form carbamino compounds; ii) allowing a degree of Cl− binding to deoxygenated haemoglobin; and iii) removing the chloride (Hamburger) shift. The insights gained could not have been obtained from empirical models. |
| spellingShingle | O'Neill, D Robbins, P A mechanistic physicochemical model of carbon dioxide transport in blood |
| title | A mechanistic physicochemical model of carbon dioxide transport in blood |
| title_full | A mechanistic physicochemical model of carbon dioxide transport in blood |
| title_fullStr | A mechanistic physicochemical model of carbon dioxide transport in blood |
| title_full_unstemmed | A mechanistic physicochemical model of carbon dioxide transport in blood |
| title_short | A mechanistic physicochemical model of carbon dioxide transport in blood |
| title_sort | mechanistic physicochemical model of carbon dioxide transport in blood |
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