Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal
While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral fle...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2025
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| _version_ | 1824459133908156416 |
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| author | Hernandez, DE Ciuparu, A Garcia da Silva, P Velasquez, CM Rebouillat, B Gross, MD Davis, MB Chae, H Muresan, RC Albeanu, DF |
| author_facet | Hernandez, DE Ciuparu, A Garcia da Silva, P Velasquez, CM Rebouillat, B Gross, MD Davis, MB Chae, H Muresan, RC Albeanu, DF |
| author_sort | Hernandez, DE |
| collection | OXFORD |
| description | While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. Responses to the same sensory cue are strongly modulated upon changes in stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton responses occurs within seconds of the rule-reversal events and is correlated with changes in behavior. Optogenetic perturbation of cortical feedback within the bulb disrupts the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback axons carry stimulus identity and reward contingency signals which are rapidly re-formatted according to changes in the behavioral context. |
| first_indexed | 2025-02-19T04:36:57Z |
| format | Journal article |
| id | oxford-uuid:d2262457-2198-4ff0-9dba-87c9fc2e820f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:36:57Z |
| publishDate | 2025 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:d2262457-2198-4ff0-9dba-87c9fc2e820f2025-02-01T20:04:01ZFast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversalJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d2262457-2198-4ff0-9dba-87c9fc2e820fEnglishJisc Publications RouterNature Research2025Hernandez, DECiuparu, AGarcia da Silva, PVelasquez, CMRebouillat, BGross, MDDavis, MBChae, HMuresan, RCAlbeanu, DFWhile animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigate whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engage head-fixed male mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues trigger responses in the cortical bulbar feedback axons which precede the behavioral report. Responses to the same sensory cue are strongly modulated upon changes in stimulus-reward contingency (rule-reversals). The re-shaping of individual bouton responses occurs within seconds of the rule-reversal events and is correlated with changes in behavior. Optogenetic perturbation of cortical feedback within the bulb disrupts the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback axons carry stimulus identity and reward contingency signals which are rapidly re-formatted according to changes in the behavioral context. |
| spellingShingle | Hernandez, DE Ciuparu, A Garcia da Silva, P Velasquez, CM Rebouillat, B Gross, MD Davis, MB Chae, H Muresan, RC Albeanu, DF Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_full | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_fullStr | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_full_unstemmed | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_short | Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal |
| title_sort | fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule reversal |
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