Hyperglycemia during childhood diarrhea.
OBJECTIVE: To determine the cause of hyperglycemia in childhood diarrhea. METHODS: During an 8-month period, patients admitted to a diarrhea treatment center in Bangladesh had their blood glucose concentrations determined. Sixteen patients aged 2 to 10 years with hyperglycemia (blood glucose concent...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797096529419304960 |
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| author | Ronan, A Azad, A Rahman, O Phillips, R Bennish, M |
| author_facet | Ronan, A Azad, A Rahman, O Phillips, R Bennish, M |
| author_sort | Ronan, A |
| collection | OXFORD |
| description | OBJECTIVE: To determine the cause of hyperglycemia in childhood diarrhea. METHODS: During an 8-month period, patients admitted to a diarrhea treatment center in Bangladesh had their blood glucose concentrations determined. Sixteen patients aged 2 to 10 years with hyperglycemia (blood glucose concentration >10.0 mmol/L) and 20 patients in the same age group with a normal blood glucose concentration (3.3 to 9.0 mmol/L) had blood samples obtained on admission and 4 and 24 hours later for determination of glucoregulatory hormones and gluconeogenic substrates. RESULTS: Prevalence of hyperglycemia among patients aged 2 to 10 years was 9.4%. Compared with the normoglycemic patients, hyperglycemic patients more often had severe dehydration (100% versus 10%, p <0.001), infection with Vibrio cholerae 0 1 or toxigenic Escherichia coli (94% vs 25%, p <0.001), and had similar duration of fasting (16 vs 14 hours, p = 0.677). Concentrations of epinephrine (7.15 vs 2.00 micromol/L), norepinephrine (10.35 vs 3.50 micromol/L), cortisol (1.38 vs 0.82 micromol/L), glucagon (36 vs 14 pmol/L), and C-peptide (1.22 vs 0.35 nmol/L) were all significantly (p < or = 0.014) higher in patients with hyperglycemia than in normoglycemic patients. CONCLUSIONS: The development of hyperglycemia in diarrhea is caused by a stress response to hypovolemia. |
| first_indexed | 2024-03-07T04:43:08Z |
| format | Journal article |
| id | oxford-uuid:d25574bf-cf31-4418-9871-e6b728c8223f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:43:08Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:d25574bf-cf31-4418-9871-e6b728c8223f2022-03-27T08:03:13ZHyperglycemia during childhood diarrhea.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d25574bf-cf31-4418-9871-e6b728c8223fEnglishSymplectic Elements at Oxford1997Ronan, AAzad, ARahman, OPhillips, RBennish, MOBJECTIVE: To determine the cause of hyperglycemia in childhood diarrhea. METHODS: During an 8-month period, patients admitted to a diarrhea treatment center in Bangladesh had their blood glucose concentrations determined. Sixteen patients aged 2 to 10 years with hyperglycemia (blood glucose concentration >10.0 mmol/L) and 20 patients in the same age group with a normal blood glucose concentration (3.3 to 9.0 mmol/L) had blood samples obtained on admission and 4 and 24 hours later for determination of glucoregulatory hormones and gluconeogenic substrates. RESULTS: Prevalence of hyperglycemia among patients aged 2 to 10 years was 9.4%. Compared with the normoglycemic patients, hyperglycemic patients more often had severe dehydration (100% versus 10%, p <0.001), infection with Vibrio cholerae 0 1 or toxigenic Escherichia coli (94% vs 25%, p <0.001), and had similar duration of fasting (16 vs 14 hours, p = 0.677). Concentrations of epinephrine (7.15 vs 2.00 micromol/L), norepinephrine (10.35 vs 3.50 micromol/L), cortisol (1.38 vs 0.82 micromol/L), glucagon (36 vs 14 pmol/L), and C-peptide (1.22 vs 0.35 nmol/L) were all significantly (p < or = 0.014) higher in patients with hyperglycemia than in normoglycemic patients. CONCLUSIONS: The development of hyperglycemia in diarrhea is caused by a stress response to hypovolemia. |
| spellingShingle | Ronan, A Azad, A Rahman, O Phillips, R Bennish, M Hyperglycemia during childhood diarrhea. |
| title | Hyperglycemia during childhood diarrhea. |
| title_full | Hyperglycemia during childhood diarrhea. |
| title_fullStr | Hyperglycemia during childhood diarrhea. |
| title_full_unstemmed | Hyperglycemia during childhood diarrhea. |
| title_short | Hyperglycemia during childhood diarrhea. |
| title_sort | hyperglycemia during childhood diarrhea |
| work_keys_str_mv | AT ronana hyperglycemiaduringchildhooddiarrhea AT azada hyperglycemiaduringchildhooddiarrhea AT rahmano hyperglycemiaduringchildhooddiarrhea AT phillipsr hyperglycemiaduringchildhooddiarrhea AT bennishm hyperglycemiaduringchildhooddiarrhea |