Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission.
We aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 transmission. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 transmission cohort including 203 mothe...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Conference item |
| Published: |
2002
|
| _version_ | 1826298193997987840 |
|---|---|
| author | Polycarpou, A Ntais, C Korber, B Elrich, H Winchester, R Krogstad, P Wolinsky, S Rostron, T Rowland-Jones, S Ammann, A Ioannidis, J |
| author_facet | Polycarpou, A Ntais, C Korber, B Elrich, H Winchester, R Krogstad, P Wolinsky, S Rostron, T Rowland-Jones, S Ammann, A Ioannidis, J |
| author_sort | Polycarpou, A |
| collection | OXFORD |
| description | We aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 transmission. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 transmission cohort including 203 mother-infant pairs, was performed by serological and molecular methods. HLA effects were evaluated alone and by multivariate modeling considering also other known predictors of perinatal HIV-1 transmission (maternal viral load, antiretroviral therapy, duration of rupture of membranes, and histological chorioamnionitis). Modest associations were seen with specific HLA markers (increased risk with infant B67 and B58 and maternal DR1; decreased risk with maternal B12), but these were not statistically significant after adjusting for multiple comparisons. Mother-infant concordance at any class I locus was a strong predictor of transmission (odds ratio [OR], 4.16; p = 0.028). Transmission was not associated with class II concordance. Class I HLA concordance retained its importance after adjusting for maternal viral load, antiretroviral therapy, duration of rupture of membranes or histological chorioamnionitis. In multivariate modeling, only class I concordance (OR, 3.59; p = 0.069) and chorioamnionitis (OR, 3.79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission. |
| first_indexed | 2024-03-07T04:43:08Z |
| format | Conference item |
| id | oxford-uuid:d255f1ea-afb7-4e2c-a696-61ee988927a1 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:43:08Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:d255f1ea-afb7-4e2c-a696-61ee988927a12022-03-27T08:03:12ZAssociation between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:d255f1ea-afb7-4e2c-a696-61ee988927a1Symplectic Elements at Oxford2002Polycarpou, ANtais, CKorber, BElrich, HWinchester, RKrogstad, PWolinsky, SRostron, TRowland-Jones, SAmmann, AIoannidis, JWe aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 transmission. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 transmission cohort including 203 mother-infant pairs, was performed by serological and molecular methods. HLA effects were evaluated alone and by multivariate modeling considering also other known predictors of perinatal HIV-1 transmission (maternal viral load, antiretroviral therapy, duration of rupture of membranes, and histological chorioamnionitis). Modest associations were seen with specific HLA markers (increased risk with infant B67 and B58 and maternal DR1; decreased risk with maternal B12), but these were not statistically significant after adjusting for multiple comparisons. Mother-infant concordance at any class I locus was a strong predictor of transmission (odds ratio [OR], 4.16; p = 0.028). Transmission was not associated with class II concordance. Class I HLA concordance retained its importance after adjusting for maternal viral load, antiretroviral therapy, duration of rupture of membranes or histological chorioamnionitis. In multivariate modeling, only class I concordance (OR, 3.59; p = 0.069) and chorioamnionitis (OR, 3.79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission. |
| spellingShingle | Polycarpou, A Ntais, C Korber, B Elrich, H Winchester, R Krogstad, P Wolinsky, S Rostron, T Rowland-Jones, S Ammann, A Ioannidis, J Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title | Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title_full | Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title_fullStr | Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title_full_unstemmed | Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title_short | Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission. |
| title_sort | association between maternal and infant class i and ii hla alleles and of their concordance with the risk of perinatal hiv type 1 transmission |
| work_keys_str_mv | AT polycarpoua associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT ntaisc associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT korberb associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT elrichh associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT winchesterr associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT krogstadp associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT wolinskys associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT rostront associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT rowlandjoness associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT ammanna associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission AT ioannidisj associationbetweenmaternalandinfantclassiandiihlaallelesandoftheirconcordancewiththeriskofperinatalhivtype1transmission |