Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

The interaction between beta-catenin and Tcf family members is crucial for the Wnt signal transduction pathway, which is commonly mutated in cancer. This interaction extends over a very large surface area (4800 A(2)), and inhibiting such interactions using low molecular weight inhibitors is a challe...

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Detalles Bibliográficos
Autores principales: Trosset, J, Dalvit, C, Knapp, S, Fasolini, M, Veronesi, M, Mantegani, S, Gianellini, L, Catana, C, Sundström, M, Stouten, P, Moll, J
Formato: Journal article
Lenguaje:English
Publicado: 2006

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