Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, in Gram-positive bacteria, include mutations to PBP...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Macheboeuf, P, Fischer, D, Brown, T, Zervosen, A, Luxen, A, Joris, B, Dessen, A, Schofield, C
Format:	Journal article
Sprache:	English
Veröffentlicht:	2007

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