A gene regulatory network orchestrates neural crest formation.
The neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the peripheral nervous system to the craniofacial skeleton and pigment cells. A multimodule gene regulatory network mediates the complex process of neura...
| मुख्य लेखकों: | , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2008
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| _version_ | 1826298215575584768 |
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| author | Sauka-Spengler, T Bronner-Fraser, M |
| author_facet | Sauka-Spengler, T Bronner-Fraser, M |
| author_sort | Sauka-Spengler, T |
| collection | OXFORD |
| description | The neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the peripheral nervous system to the craniofacial skeleton and pigment cells. A multimodule gene regulatory network mediates the complex process of neural crest formation, which involves the early induction and maintenance of the precursor pool, emigration of the neural crest progenitors from the neural tube via an epithelial to mesenchymal transition, migration of progenitor cells along distinct pathways and overt differentiation into diverse cell types. Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network. |
| first_indexed | 2024-03-07T04:43:28Z |
| format | Journal article |
| id | oxford-uuid:d2718b2e-85c9-4948-9aca-3cf5feac43c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:43:28Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:d2718b2e-85c9-4948-9aca-3cf5feac43c52022-03-27T08:03:59ZA gene regulatory network orchestrates neural crest formation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d2718b2e-85c9-4948-9aca-3cf5feac43c5EnglishSymplectic Elements at Oxford2008Sauka-Spengler, TBronner-Fraser, MThe neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the peripheral nervous system to the craniofacial skeleton and pigment cells. A multimodule gene regulatory network mediates the complex process of neural crest formation, which involves the early induction and maintenance of the precursor pool, emigration of the neural crest progenitors from the neural tube via an epithelial to mesenchymal transition, migration of progenitor cells along distinct pathways and overt differentiation into diverse cell types. Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network. |
| spellingShingle | Sauka-Spengler, T Bronner-Fraser, M A gene regulatory network orchestrates neural crest formation. |
| title | A gene regulatory network orchestrates neural crest formation. |
| title_full | A gene regulatory network orchestrates neural crest formation. |
| title_fullStr | A gene regulatory network orchestrates neural crest formation. |
| title_full_unstemmed | A gene regulatory network orchestrates neural crest formation. |
| title_short | A gene regulatory network orchestrates neural crest formation. |
| title_sort | gene regulatory network orchestrates neural crest formation |
| work_keys_str_mv | AT saukaspenglert ageneregulatorynetworkorchestratesneuralcrestformation AT bronnerfraserm ageneregulatorynetworkorchestratesneuralcrestformation AT saukaspenglert generegulatorynetworkorchestratesneuralcrestformation AT bronnerfraserm generegulatorynetworkorchestratesneuralcrestformation |