A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders
Developing new tools to better understand disorders of the nervous system, with a goal to more effectively treat them, is an active area of bioelectronic medicine research. Future tools must be flexible and configurable, given the evolving understanding of both neuromodulation mechanisms and how to...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
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Institute of Electrical and Electronics Engineers
2018
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| _version_ | 1797096554665869312 |
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| author | Stanslaski, S Herron, J Chouinard, T Bourget, D Isaacson, B Kremen, V Opri, E Drew, W Brinkmann, B Gunduz, A Adamski, T Worrell, G Denison, T |
| author_facet | Stanslaski, S Herron, J Chouinard, T Bourget, D Isaacson, B Kremen, V Opri, E Drew, W Brinkmann, B Gunduz, A Adamski, T Worrell, G Denison, T |
| author_sort | Stanslaski, S |
| collection | OXFORD |
| description | Developing new tools to better understand disorders of the nervous system, with a goal to more effectively treat them, is an active area of bioelectronic medicine research. Future tools must be flexible and configurable, given the evolving understanding of both neuromodulation mechanisms and how to configure a system for optimal clinical outcomes. We describe a system, the SummitTM RC+S “neural coprocessor,” that attempts to bring the capability and flexibility of a microprocessor to a prosthesis embedded within the nervous system. The paper describes the updated system architecture for the SummitTM RC+S system, the five custom integrated circuits required for bidirectional neural interfacing, the supporting firmware/software ecosystem, and the verification and validation activities to prepare for human implantation. Emphasis is placed on design changes motivated by experience with the CE-marked ActivaTM PC+S research tool; specifically, enhancement of sense-stim performance for improved bi-directional communication to the nervous system, implementation of rechargeable technology to extend device longevity, and application of MICS-band telemetry for algorithm development and data management. The technology was validated in a chronic treatment paradigm for canines with naturally-occurring epilepsy, including free ambulation in the home environment, which represents a typical use case for future human protocols. |
| first_indexed | 2024-03-07T04:43:30Z |
| format | Journal article |
| id | oxford-uuid:d27490af-106d-4a8b-b1ca-608c975b3d5b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:43:30Z |
| publishDate | 2018 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | oxford-uuid:d27490af-106d-4a8b-b1ca-608c975b3d5b2022-03-27T08:04:08ZA chronically-implantable neural coprocessor for investigating the treatment of neurological disordersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d27490af-106d-4a8b-b1ca-608c975b3d5bSymplectic Elements at OxfordInstitute of Electrical and Electronics Engineers2018Stanslaski, SHerron, JChouinard, TBourget, DIsaacson, BKremen, VOpri, EDrew, WBrinkmann, BGunduz, AAdamski, TWorrell, GDenison, TDeveloping new tools to better understand disorders of the nervous system, with a goal to more effectively treat them, is an active area of bioelectronic medicine research. Future tools must be flexible and configurable, given the evolving understanding of both neuromodulation mechanisms and how to configure a system for optimal clinical outcomes. We describe a system, the SummitTM RC+S “neural coprocessor,” that attempts to bring the capability and flexibility of a microprocessor to a prosthesis embedded within the nervous system. The paper describes the updated system architecture for the SummitTM RC+S system, the five custom integrated circuits required for bidirectional neural interfacing, the supporting firmware/software ecosystem, and the verification and validation activities to prepare for human implantation. Emphasis is placed on design changes motivated by experience with the CE-marked ActivaTM PC+S research tool; specifically, enhancement of sense-stim performance for improved bi-directional communication to the nervous system, implementation of rechargeable technology to extend device longevity, and application of MICS-band telemetry for algorithm development and data management. The technology was validated in a chronic treatment paradigm for canines with naturally-occurring epilepsy, including free ambulation in the home environment, which represents a typical use case for future human protocols. |
| spellingShingle | Stanslaski, S Herron, J Chouinard, T Bourget, D Isaacson, B Kremen, V Opri, E Drew, W Brinkmann, B Gunduz, A Adamski, T Worrell, G Denison, T A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title | A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title_full | A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title_fullStr | A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title_full_unstemmed | A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title_short | A chronically-implantable neural coprocessor for investigating the treatment of neurological disorders |
| title_sort | chronically implantable neural coprocessor for investigating the treatment of neurological disorders |
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