Therapeutic targeting of histone H3 lysine 36 trimethylation-deficient cancers
<p>Histone modifications play diverse and essential roles in the maintenance of genome integrity, as evidenced by the frequency at which different histone marks are dysregulated during tumourigenesis. The trimethylation of histone H3 at lysine 36 (H3K36me3) and SETD2, the enzyme solely respons...
Príomhchruthaitheoir: | Lopez, K |
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Rannpháirtithe: | Humphrey, T |
Formáid: | Tráchtas |
Teanga: | English |
Foilsithe / Cruthaithe: |
2019
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Ábhair: |
Míreanna comhchosúla
Míreanna comhchosúla
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The three methyls: the function and therapeutic potential of histone H3K36 trimethylation
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SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters
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Distribution and maintenance of histone H3 lysine 36 trimethylation in transcribed locus.
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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
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Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene
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