The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.

We have studied the role of carbonic anhydrase 9 (CA9), a cancer-associated extracellular isoform of the enzyme carbonic anhydrase in multicellular spheroid growths (radius of approximately 300 microm) of human colon carcinoma HCT116 cells. Spheroids were transfected with CA9 (or empty vector) and i...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Swietach, P, Patiar, S, Supuran, C, Harris, A, Vaughan-Jones, R
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2009

Παρόμοια τεκμήρια

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
ανά: Swietach, P, κ.ά.
Έκδοση: (2008)

Regulation of tumor pH and the role of carbonic anhydrase 9.
ανά: Swietach, P, κ.ά.
Έκδοση: (2007)

Carbonic anhydrase IX unifies spatial pH(i) regulation in large cell-clusters
ανά: Swietach, P, κ.ά.
Έκδοση: (2007)

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
ανά: Swietach, P, κ.ά.
Έκδοση: (2012)

Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure
ανά: Hulikova, A, κ.ά.
Έκδοση: (2014)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
ανά: Swietach, P, κ.ά.
Έκδοση: (2010)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
ανά: Swietach, P, κ.ά.
Έκδοση: (2010)

Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.
ανά: Hulikova, A, κ.ά.
Έκδοση: (2011)

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.
ανά: Pawel Swietach, κ.ά.
Έκδοση: (2012-01-01)

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.
ανά: Swietach, P, κ.ά.
Έκδοση: (2008)

Facilitation by intracellular carbonic anhydrase of Na-HCO co-transport but not Na/H exchange activity in the mammalian ventricular myocyte
ανά: Villafuerte, F, κ.ά.
Έκδοση: (2014)

Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.
ανά: McIntyre, A, κ.ά.
Έκδοση: (2012)

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
ανά: Lee, S-H, κ.ά.
Έκδοση: (2018)

Facilitation by intracellular carbonic anhydrase of Na+–HCO3− co‐transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte
ανά: Villafuerte, F, κ.ά.
Έκδοση: (2013)

Facilitation by intracellular carbonic anhydrase of Na+-HCO3 - co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte
ανά: Villafuerte, F, κ.ά.
Έκδοση: (2014)

Intracellular pH regulation in heart.
ανά: Vaughan-Jones, R, κ.ά.
Έκδοση: (2009)

Spatial regulation of intracellular pH in the ventricular myocyte.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors
ανά: Claudiu T. Supuran
Έκδοση: (2017-09-01)

Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.
ανά: Schroeder, M, κ.ά.
Έκδοση: (2013)

Common inhibitors of membrane H+-transport also inhibit carbonic anhydrase
ανά: Villafuerte, F, κ.ά.
Έκδοση: (2007)

An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics
ανά: Schroeder, M, κ.ά.
Έκδοση: (2013)

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
ανά: Hulikova, A, κ.ά.
Έκδοση: (2013)

Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors
ανά: Supuran CT
Έκδοση: (2020-12-01)

Spatial aspects of intracellular pH regulation in heart muscle.
ανά: Vaughan-Jones, R, κ.ά.
Έκδοση: (2006)

Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism
ανά: Claudiu T. Supuran
Έκδοση: (2023-11-01)

The relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
ανά: Bountra, C, κ.ά.
Έκδοση: (1989)

Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

An Overview of the Bacterial Carbonic Anhydrases
ανά: Claudiu T. Supuran, κ.ά.
Έκδοση: (2017-11-01)

Spatial Control of pH(i) in the Heart, and Its Influence on the Local Control of Intracellular Ca2+ Signaling
ανά: Vaughan-Jones, R, κ.ά.
Έκδοση: (2009)

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2015)

Polyamines and α-Carbonic Anhydrases
ανά: Andrea Scozzafava, κ.ά.
Έκδοση: (2016-12-01)

Acipimox inhibits human carbonic anhydrases
ανά: Mattia Mori, κ.ά.
Έκδοση: (2022-12-01)

H⁺-activated Na⁺ influx in the ventricular myocyte couples Ca²⁺-signalling to intracellular pH.
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.
ανά: Swietach, P, κ.ά.
Έκδοση: (2010)

Local release of caged protons by UV flash photolysis as a means of producing intracellular pH non-uniformity
ανά: Swietach, P, κ.ά.
Έκδοση: (2005)

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
ανά: Garciarena, C, κ.ά.
Έκδοση: (2013)

Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
ανά: Anastasia Karioti, κ.ά.
Έκδοση: (2016-12-01)

Carbonic Anhydrase Inhibitors from Marine Natural Products
ανά: Claudiu T. Supuran
Έκδοση: (2022-11-01)