Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup-emerging targets to combat antibiotic resistance

β-Lactams are the most widely employed antibiotics in clinical settings due to their broad efficacy and low toxicity. However, since their first use in the 1940s, resistance to β-lactams has proliferated to the point where multi-drug resistant organisms are now one of the greatest threats to global...

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Bibliographic Details
Main Authors: Krco, S, Davis, SJ, Joshi, P, Wilson, LA, Monteiro Pedroso, M, Douw, A, Schofield, CJ, Hugenholtz, P, Schenk, G, Morris, MT
Format: Journal article
Language:English
Published: Frontiers Media 2023