Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.
The effects of the immunosuppressant Cyclosporin A (CsA) on T cell activation in vivo and in vitro were examined using the monoclonal antibody, anti-Tac, for interleukin 2 (IL-2) receptors and 3.9C2, for a peptide fragment of human IL-2. Peripheral blood lymphocytes (PBL) were stimulated with PHA in...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1987
|
| _version_ | 1797096653584334848 |
|---|---|
| author | Calder, V Bellamy, A Owen, S Lewis, C Rudge, P Davison, A Feldmann, M |
| author_facet | Calder, V Bellamy, A Owen, S Lewis, C Rudge, P Davison, A Feldmann, M |
| author_sort | Calder, V |
| collection | OXFORD |
| description | The effects of the immunosuppressant Cyclosporin A (CsA) on T cell activation in vivo and in vitro were examined using the monoclonal antibody, anti-Tac, for interleukin 2 (IL-2) receptors and 3.9C2, for a peptide fragment of human IL-2. Peripheral blood lymphocytes (PBL) were stimulated with PHA in the presence of CsA. The expression of IL-2 receptors and production of IL-2 were reduced. PBL from CsA-treated MS patients had significantly lower proportions of Tac+ cells compared with untreated patients. This inhibition was not reflected in the CSF lymphocyte populations from CsA-treated patients and indicates the urgent need for an immunosuppressant drug which can enter the CNS in sufficient concentrations to inhibit local T cell activation. |
| first_indexed | 2024-03-07T04:44:36Z |
| format | Journal article |
| id | oxford-uuid:d2cdad6e-acee-4db7-a653-4e086228e9ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:44:36Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:d2cdad6e-acee-4db7-a653-4e086228e9ab2022-03-27T08:06:46ZEffects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d2cdad6e-acee-4db7-a653-4e086228e9abEnglishSymplectic Elements at Oxford1987Calder, VBellamy, AOwen, SLewis, CRudge, PDavison, AFeldmann, MThe effects of the immunosuppressant Cyclosporin A (CsA) on T cell activation in vivo and in vitro were examined using the monoclonal antibody, anti-Tac, for interleukin 2 (IL-2) receptors and 3.9C2, for a peptide fragment of human IL-2. Peripheral blood lymphocytes (PBL) were stimulated with PHA in the presence of CsA. The expression of IL-2 receptors and production of IL-2 were reduced. PBL from CsA-treated MS patients had significantly lower proportions of Tac+ cells compared with untreated patients. This inhibition was not reflected in the CSF lymphocyte populations from CsA-treated patients and indicates the urgent need for an immunosuppressant drug which can enter the CNS in sufficient concentrations to inhibit local T cell activation. |
| spellingShingle | Calder, V Bellamy, A Owen, S Lewis, C Rudge, P Davison, A Feldmann, M Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title | Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title_full | Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title_fullStr | Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title_full_unstemmed | Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title_short | Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. |
| title_sort | effects of cyclosporin a on expression of il 2 and il 2 receptors in normal and multiple sclerosis patients |
| work_keys_str_mv | AT calderv effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT bellamya effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT owens effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT lewisc effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT rudgep effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT davisona effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients AT feldmannm effectsofcyclosporinaonexpressionofil2andil2receptorsinnormalandmultiplesclerosispatients |