The fixation probability of two competing beneficial mutations.
Suppose that a beneficial mutation is undergoing a selective sweep when another beneficial mutation arises at a linked locus. We study the fixation probability of the double mutant, i.e., one (produced by recombination) that carries both mutations. Previous analysis works well for the case where the...
| Príomhchruthaitheoirí: | , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2010
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| _version_ | 1826298353751687168 |
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| author | Yu, F Etheridge, A |
| author_facet | Yu, F Etheridge, A |
| author_sort | Yu, F |
| collection | OXFORD |
| description | Suppose that a beneficial mutation is undergoing a selective sweep when another beneficial mutation arises at a linked locus. We study the fixation probability of the double mutant, i.e., one (produced by recombination) that carries both mutations. Previous analysis works well for the case where the earlier beneficial mutation confers a greater selective advantage than the later mutation, but not so well in the opposite case. We present an approach to approximating the fixation probability in the case where the later mutation confers a greater selective advantage. |
| first_indexed | 2024-03-07T04:45:33Z |
| format | Journal article |
| id | oxford-uuid:d32182cf-02ee-4b46-a644-e9152d128ec3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:45:33Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:d32182cf-02ee-4b46-a644-e9152d128ec32022-03-27T08:09:05ZThe fixation probability of two competing beneficial mutations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d32182cf-02ee-4b46-a644-e9152d128ec3EnglishSymplectic Elements at Oxford2010Yu, FEtheridge, ASuppose that a beneficial mutation is undergoing a selective sweep when another beneficial mutation arises at a linked locus. We study the fixation probability of the double mutant, i.e., one (produced by recombination) that carries both mutations. Previous analysis works well for the case where the earlier beneficial mutation confers a greater selective advantage than the later mutation, but not so well in the opposite case. We present an approach to approximating the fixation probability in the case where the later mutation confers a greater selective advantage. |
| spellingShingle | Yu, F Etheridge, A The fixation probability of two competing beneficial mutations. |
| title | The fixation probability of two competing beneficial mutations. |
| title_full | The fixation probability of two competing beneficial mutations. |
| title_fullStr | The fixation probability of two competing beneficial mutations. |
| title_full_unstemmed | The fixation probability of two competing beneficial mutations. |
| title_short | The fixation probability of two competing beneficial mutations. |
| title_sort | fixation probability of two competing beneficial mutations |
| work_keys_str_mv | AT yuf thefixationprobabilityoftwocompetingbeneficialmutations AT etheridgea thefixationprobabilityoftwocompetingbeneficialmutations AT yuf fixationprobabilityoftwocompetingbeneficialmutations AT etheridgea fixationprobabilityoftwocompetingbeneficialmutations |