Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model
Randomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patients with OSA. Short-term CPAP withdrawal in patients with prior...
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| Format: | Journal article |
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AME Publishing Company
2018
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| _version_ | 1797096724322320384 |
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| author | Schwarz, E Stradling, J Kohler, M |
| author_facet | Schwarz, E Stradling, J Kohler, M |
| author_sort | Schwarz, E |
| collection | OXFORD |
| description | Randomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patients with OSA. Short-term CPAP withdrawal in patients with prior optimal CPAP adherence results in recurrence of OSA and its consequences. Thus, this experimental model serves as an efficient tool to investigate both the consequences of untreated OSA, and potential treatment alternatives to CPAP. The CPAP withdrawal protocol has been thoroughly validated, and applied in several RCTs focusing on cardiovascular and metabolic consequences of untreated OSA, as well as the assessment of treatment alternatives to CPAP. |
| first_indexed | 2024-03-07T04:45:37Z |
| format | Journal article |
| id | oxford-uuid:d3278ce9-1866-43b4-a113-7812b946b77f |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:45:37Z |
| publishDate | 2018 |
| publisher | AME Publishing Company |
| record_format | dspace |
| spelling | oxford-uuid:d3278ce9-1866-43b4-a113-7812b946b77f2022-03-27T08:09:20ZPhysiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental modelJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d3278ce9-1866-43b4-a113-7812b946b77fSymplectic Elements at OxfordAME Publishing Company2018Schwarz, EStradling, JKohler, MRandomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patients with OSA. Short-term CPAP withdrawal in patients with prior optimal CPAP adherence results in recurrence of OSA and its consequences. Thus, this experimental model serves as an efficient tool to investigate both the consequences of untreated OSA, and potential treatment alternatives to CPAP. The CPAP withdrawal protocol has been thoroughly validated, and applied in several RCTs focusing on cardiovascular and metabolic consequences of untreated OSA, as well as the assessment of treatment alternatives to CPAP. |
| spellingShingle | Schwarz, E Stradling, J Kohler, M Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title | Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title_full | Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title_fullStr | Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title_full_unstemmed | Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title_short | Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-An opportunity for an efficient experimental model |
| title_sort | physiological consequences of cpap therapy withdrawal in patients with obstructive sleep apnoea an opportunity for an efficient experimental model |
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