Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.

Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca(2+) signaling pathways. Malfunctioning Ca(2+) regulation in PC2 causes autosomal-dominant polycystic kidney disease. Here we report two cryo-EM structures of distinct channel states of full-length human PC2 in comp...

Full description

Bibliographic Details
Main Authors: Wilkes, M, Madej, M, Kreuter, L, Rhinow, D, Heinz, V, De Sanctis, S, Ruppel, S, Richter, R, Joos, F, Grieben, M, Pike, A, Huiskonen, J, Carpenter, E, Kühlbrandt, W, Witzgall, R, Ziegler, C
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

Similar Items

Similar Items