Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Show other versions (2)

Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. Here, we have developed a novel functional genomics methodology to express common locus haplotypes to assess functional differences. DNA recombination was used to...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Hamilton, G, Killick, R, Genetic, A, Translational, G, Lambert, J, Amouyel, P, European, A, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2012

Antzeko izenburuak

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.
nork: Hamilton, G, et al.
Argitaratua: (2012)

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus
nork: Hamilton, G, et al.
Argitaratua: (2012)

Haplotype-specific expression of exon 10 at the human MAPT locus
nork: Caffrey, T, et al.
Argitaratua: (2006)

Haplotype-specific expression of exon 10 at the human MAPT locus.
nork: Caffrey, T, et al.
Argitaratua: (2006)

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus.
nork: Caffrey, T, et al.
Argitaratua: (2008)

Haplotypic analysis of the TNF locus by association efficiency and entropy
nork: Ackerman, H, et al.
Argitaratua: (2003)

Haplotypic analysis of the TNF locus by association efficiency and entropy.
nork: Ackerman, H, et al.
Argitaratua: (2003)

Bayesian quantitative trait locus mapping using inferred haplotypes.
nork: Durrant, C, et al.
Argitaratua: (2010)

Antibody Responses and the Vaccine Efficacy of Recombinant Glycosyltransferase and Nicastrin Against <i>Schistosoma japonicum</i>
nork: Bowen Dong, et al.
Argitaratua: (2025-01-01)

Haplotype mapping of the bronchiolitis susceptibility locus near IL8.
nork: Hull, J, et al.
Argitaratua: (2004)

Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
nork: Kamihara-Ting, Junne
Argitaratua: (2008)

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer
nork: Lu Yan, et al.
Argitaratua: (2024-12-01)

DNA polymorphism, haplotype structure and balancing selection in the Leavenworthia PgiC locus.
nork: Filatov, D, et al.
Argitaratua: (1999)

HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia.
nork: Maitland, K, et al.
Argitaratua: (2004)

Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus.
nork: Hull, J, et al.
Argitaratua: (2001)

Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations.
nork: Burgner, D, et al.
Argitaratua: (2003)

Functional MAPT haplotypes: bridging the gap between genotype and neuropathology.
nork: Caffrey, T, et al.
Argitaratua: (2007)

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
nork: Bell, C, et al.
Argitaratua: (2010)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.
nork: Chao, M, et al.
Argitaratua: (2007)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
nork: Chao, M, et al.
Argitaratua: (2007)

Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms
nork: Forton, J, et al.
Argitaratua: (2005)

Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms.
nork: Forton, J, et al.
Argitaratua: (2005)

Genetics: The MAPT locus-a genetic paradigm in disease susceptibility.
nork: Wade-Martins, R
Argitaratua: (2012)

Haplotype studies in Wilson disease.
nork: Thomas, G, et al.
Argitaratua: (1994)

A haplotype map for the laboratory mouse.
nork: Mott, R
Argitaratua: (2007)

MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
nork: Kristen J. Wade, et al.
Argitaratua: (2024-10-01)

HLA haplotype associations with disease.
nork: Thomson, G, et al.
Argitaratua: (1979)

Expression of the KIAA0319 gene from a haplotype associated with developmental dyslexia
nork: Dennis, M, et al.
Argitaratua: (2006)

Absence of relationship between MTTP haplotypes and longevity.
nork: Neville, M, et al.
Argitaratua: (2007)

Haplotype tagging for the identification of common disease genes.
nork: Johnson, G, et al.
Argitaratua: (2001)

Haplotype structure and selection of the MDM2 oncogene in humans.
nork: Atwal, G, et al.
Argitaratua: (2007)

An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
nork: Jaeger, E, et al.
Argitaratua: (2003)

Genomic sequence of 'Candidatus Liberibacter solanacearum' haplotype C and its comparison with haplotype A and B genomes.
nork: Jinhui Wang, et al.
Argitaratua: (2017-01-01)

Novel alpha haemoglobin haplotypes in horses.
nork: Bowling, A, et al.
Argitaratua: (1988)

Efficient haplotyping for families
nork: Williams, Amy Lynne, Ph.D. Massachusetts Institute of Technology
Argitaratua: (2010)

Haplotype estimation using sequencing reads.
nork: Delaneau, O, et al.
Argitaratua: (2013)

Dissection of the multiple sclerosis associated DR2 haplotype.
nork: Etzensperger, R, et al.
Argitaratua: (2008)

A dinucleotide repeat polymorphism at the DMD locus.
nork: Powell, J, et al.
Argitaratua: (1991)

Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study
nork: Xue, M, et al.
Argitaratua: (2005)

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
nork: Lai, M, et al.
Argitaratua: (2017)