Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Показать другие версии (2)

Nicastrin (NCSTN) is a component of the γ-secretase complex and therefore potentially a candidate risk gene for Alzheimer's disease. Here, we have developed a novel functional genomics methodology to express common locus haplotypes to assess functional differences. DNA recombination was used to...

Полное описание

Библиографические подробности
Главные авторы:	Hamilton, G, Killick, R, Genetic, A, Translational, G, Lambert, J, Amouyel, P, European, A, Carrasquillo, M, Pankratz, V, Graff-Radford, N, Dickson, D, Petersen, R, Younkin, S, Powell, J, Wade-Martins, R
Формат:	Journal article
Язык:	English
Опубликовано:	2012

Схожие документы

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.
по: Hamilton, G, и др.
Опубликовано: (2012)

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus
по: Hamilton, G, и др.
Опубликовано: (2012)

Haplotype-specific expression of exon 10 at the human MAPT locus
по: Caffrey, T, и др.
Опубликовано: (2006)

Haplotype-specific expression of exon 10 at the human MAPT locus.
по: Caffrey, T, и др.
Опубликовано: (2006)

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus.
по: Caffrey, T, и др.
Опубликовано: (2008)

Haplotypic analysis of the TNF locus by association efficiency and entropy
по: Ackerman, H, и др.
Опубликовано: (2003)

Haplotypic analysis of the TNF locus by association efficiency and entropy.
по: Ackerman, H, и др.
Опубликовано: (2003)

Bayesian quantitative trait locus mapping using inferred haplotypes.
по: Durrant, C, и др.
Опубликовано: (2010)

Antibody Responses and the Vaccine Efficacy of Recombinant Glycosyltransferase and Nicastrin Against <i>Schistosoma japonicum</i>
по: Bowen Dong, и др.
Опубликовано: (2025-01-01)

Haplotype mapping of the bronchiolitis susceptibility locus near IL8.
по: Hull, J, и др.
Опубликовано: (2004)

Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
по: Kamihara-Ting, Junne
Опубликовано: (2008)

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer
по: Lu Yan, и др.
Опубликовано: (2024-12-01)

DNA polymorphism, haplotype structure and balancing selection in the Leavenworthia PgiC locus.
по: Filatov, D, и др.
Опубликовано: (1999)

HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia.
по: Maitland, K, и др.
Опубликовано: (2004)

Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus.
по: Hull, J, и др.
Опубликовано: (2001)

Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations.
по: Burgner, D, и др.
Опубликовано: (2003)

Functional MAPT haplotypes: bridging the gap between genotype and neuropathology.
по: Caffrey, T, и др.
Опубликовано: (2007)

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
по: Bell, C, и др.
Опубликовано: (2010)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.
по: Chao, M, и др.
Опубликовано: (2007)

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
по: Chao, M, и др.
Опубликовано: (2007)

Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms
по: Forton, J, и др.
Опубликовано: (2005)

Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms.
по: Forton, J, и др.
Опубликовано: (2005)

Genetics: The MAPT locus-a genetic paradigm in disease susceptibility.
по: Wade-Martins, R
Опубликовано: (2012)

Haplotype studies in Wilson disease.
по: Thomas, G, и др.
Опубликовано: (1994)

A haplotype map for the laboratory mouse.
по: Mott, R
Опубликовано: (2007)

MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge
по: Kristen J. Wade, и др.
Опубликовано: (2024-10-01)

HLA haplotype associations with disease.
по: Thomson, G, и др.
Опубликовано: (1979)

Expression of the KIAA0319 gene from a haplotype associated with developmental dyslexia
по: Dennis, M, и др.
Опубликовано: (2006)

Absence of relationship between MTTP haplotypes and longevity.
по: Neville, M, и др.
Опубликовано: (2007)

Haplotype tagging for the identification of common disease genes.
по: Johnson, G, и др.
Опубликовано: (2001)

Haplotype structure and selection of the MDM2 oncogene in humans.
по: Atwal, G, и др.
Опубликовано: (2007)

An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
по: Jaeger, E, и др.
Опубликовано: (2003)

Genomic sequence of 'Candidatus Liberibacter solanacearum' haplotype C and its comparison with haplotype A and B genomes.
по: Jinhui Wang, и др.
Опубликовано: (2017-01-01)

Novel alpha haemoglobin haplotypes in horses.
по: Bowling, A, и др.
Опубликовано: (1988)

Efficient haplotyping for families
по: Williams, Amy Lynne, Ph.D. Massachusetts Institute of Technology
Опубликовано: (2010)

Haplotype estimation using sequencing reads.
по: Delaneau, O, и др.
Опубликовано: (2013)

Dissection of the multiple sclerosis associated DR2 haplotype.
по: Etzensperger, R, и др.
Опубликовано: (2008)

A dinucleotide repeat polymorphism at the DMD locus.
по: Powell, J, и др.
Опубликовано: (1991)

Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study
по: Xue, M, и др.
Опубликовано: (2005)

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
по: Lai, M, и др.
Опубликовано: (2017)