Type I-IFNs control GVHD and GVL responses after transplantation.

Type I-IFNs control GVHD and GVL responses after transplantation.

Although the effects of type II-IFN (IFN-γ) on GVHD and leukemia relapse are well studied, the effects of type I-interferon (type I-IFN, IFN-α/β) remain unclear. We investigated this using type I-IFN receptor-deficient mice and exogenous IFN-α administration in established models of GVHD and GVL. Ty...

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Main Authors: Robb, R, Kreijveld, E, Kuns, R, Wilson, Y, Olver, S, Don, A, Raffelt, N, De Weerd, N, Lineburg, K, Varelias, A, Markey, K, Koyama, M, Clouston, A, Hertzog, P, Macdonald, K, Hill, G
Format: Journal article
Language:English
Published: 2011

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