Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs

Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs

Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increa...

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מידע ביבליוגרפי
Main Authors: Yi, G, Ye, M, Carrique, L, El-Sagheer, A, Brown, T, Norbury, CJ, Zhang, P, Gilbert, RJC
פורמט: Journal article
שפה:English
יצא לאור: Nature Research 2024

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