Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increa...
Main Authors: | Yi, G, Ye, M, Carrique, L, El-Sagheer, A, Brown, T, Norbury, CJ, Zhang, P, Gilbert, RJC |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2024
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