Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs

Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs

Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either promote let-7 maturation by adding a single uridine nucleotide to the pre-miRNA 3′ end or mark them for degradation by the addition of multiple uridines. Oligo-uridylation is increa...

Полное описание

Библиографические подробности
Главные авторы:	Yi, G, Ye, M, Carrique, L, El-Sagheer, A, Brown, T, Norbury, CJ, Zhang, P, Gilbert, RJC
Формат:	Journal article
Язык:	English
Опубликовано:	Nature Research 2024

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