New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.

Glycosphingolipid lysosomal storage diseases are a small but challenging group of human disorders to treat. Although these appear to be monogenic disorders where the catalytic activity of enzymes in glycosphingolipid catabolism is impaired, the presentation and severity of disease is heterogeneous....

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Butters, T, Dwek, R, Platt, F
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2003

समान संसाधन

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Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
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Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis
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Lysosomal dysfunction and glycosphingolipid dysregulation in rare and common neurodegenerative diseases
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Introduction: Glycosphingolipids in cell biology and disease.
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Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.
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