New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.

Glycosphingolipid lysosomal storage diseases are a small but challenging group of human disorders to treat. Although these appear to be monogenic disorders where the catalytic activity of enzymes in glycosphingolipid catabolism is impaired, the presentation and severity of disease is heterogeneous....

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Bibliografiske detaljer
Main Authors:	Butters, T, Dwek, R, Platt, F
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
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Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
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Udgivet: (2000)

Substrate deprivation: a new therapeutic approach for the glycosphingolipid lysosomal storage diseases.
af: Platt, F, et al.
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New developments in treating glycosphingolipid storage diseases.
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Udgivet: (2005)

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Udgivet: (2008)

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells.
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Udgivet: (2010)

Therapeutic applications of imino sugars in lysosomal storage disorders.
af: Butters, T, et al.
Udgivet: (2003)

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases
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Udgivet: (2005)

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
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Udgivet: (2006)

Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders.
af: Butters, T, et al.
Udgivet: (2003)

Storage solutions: treating lysosomal disorders of the brain.
af: Jeyakumar, M, et al.
Udgivet: (2005)

N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo.
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Udgivet: (2000)

Iminosugar inhibitors for treating the lysosomal glycosphingolipidoses
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Udgivet: (2005)

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
af: Butters, T, et al.
Udgivet: (2005)

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Udgivet: (2004)

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Udgivet: (2002)

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases
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Udgivet: (2014-07-01)

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Udgivet: (2011)

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af: Butters, T, et al.
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Changes in glycosphingolipid levels in plasma and cerebrospinal fluid of individuals with Lysosomal Free Sialic Acid Storage Disorder
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Udgivet: (2025-01-01)

Glycosphingolipid disorders of the brain.
af: Boomkamp, S, et al.
Udgivet: (2008)

Lysosomal dysfunction and glycosphingolipid dysregulation in rare and common neurodegenerative diseases
af: Huebecker, M
Udgivet: (2019)

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Udgivet: (2004)

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Udgivet: (2004)

Lysosomal storage diseases
af: Platt, F, et al.
Udgivet: (2018)

Glycosphingolipids and Infection. Potential New Therapeutic Avenues
af: Johannes M. F. G. Aerts, et al.
Udgivet: (2019-12-01)

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Udgivet: (2011)

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Udgivet: (2004)

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Udgivet: (2010)

Inhibition of substrate synthesis as a strategy for glycolipid lysosomal storage disease therapy.
af: Platt, F, et al.
Udgivet: (2001)

Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice.
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Udgivet: (2002)

Emptying the stores: lysosomal diseases and therapeutic strategies
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Udgivet: (2017)

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Udgivet: (2004)

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
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Udgivet: (2011)

Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders.
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Udgivet: (2007)

Therapeutic Approaches in Lysosomal Storage Diseases
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Udgivet: (2021-11-01)

The apo E gene knockout mouse as a model to study the potential atherogenic properties of glycosphingolipids
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Udgivet: (2003)