Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.

The insulin-like growth factor (IGF) type 1 receptor is required for growth, transformation, and protection from apoptosis. IGFs can enhance cell migration, which is known to be influenced via regulation of the E-cadherin/beta-catenin complex. We sought to investigate whether IGF-1 modulated the int...

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Hlavní autoři: Playford, M, Bicknell, D, Bodmer, W, Macaulay, V
Médium: Journal article
Jazyk:English
Vydáno: 2000