Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns u...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2022
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| _version_ | 1797110116928978944 |
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| author | Nyberg, L Andersson, M Lundquist, A Baaré, WFC Bartrés-Faz, D Bertram, L Boraxbekk, C-J Brandmaier, AM Demnitz, N Drevon, CA Duezel, S Ebmeier, KP Ghisletta, P Henson, R Jensen, DEA Kievit, RA Knights, E Kühn, S Lindenberger, U Plachti, A Pudas, S Roe, JM Skak Madsen, K Solé Padullés, C Sommerer, Y Suri, S Zsoldos, E Fjell, AM Walhovd, KB |
| author_facet | Nyberg, L Andersson, M Lundquist, A Baaré, WFC Bartrés-Faz, D Bertram, L Boraxbekk, C-J Brandmaier, AM Demnitz, N Drevon, CA Duezel, S Ebmeier, KP Ghisletta, P Henson, R Jensen, DEA Kievit, RA Knights, E Kühn, S Lindenberger, U Plachti, A Pudas, S Roe, JM Skak Madsen, K Solé Padullés, C Sommerer, Y Suri, S Zsoldos, E Fjell, AM Walhovd, KB |
| author_sort | Nyberg, L |
| collection | OXFORD |
| description | It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems. |
| first_indexed | 2024-03-07T07:50:36Z |
| format | Journal article |
| id | oxford-uuid:d36255a0-03cb-4636-a2dd-0d7ff74a9c1a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:50:36Z |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:d36255a0-03cb-4636-a2dd-0d7ff74a9c1a2023-07-04T10:06:18ZIndividual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy ratesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d36255a0-03cb-4636-a2dd-0d7ff74a9c1aEnglishSymplectic ElementsOxford University Press2022Nyberg, LAndersson, MLundquist, ABaaré, WFCBartrés-Faz, DBertram, LBoraxbekk, C-JBrandmaier, AMDemnitz, NDrevon, CADuezel, SEbmeier, KPGhisletta, PHenson, RJensen, DEAKievit, RAKnights, EKühn, SLindenberger, UPlachti, APudas, SRoe, JMSkak Madsen, KSolé Padullés, CSommerer, YSuri, SZsoldos, EFjell, AMWalhovd, KBIt is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems. |
| spellingShingle | Nyberg, L Andersson, M Lundquist, A Baaré, WFC Bartrés-Faz, D Bertram, L Boraxbekk, C-J Brandmaier, AM Demnitz, N Drevon, CA Duezel, S Ebmeier, KP Ghisletta, P Henson, R Jensen, DEA Kievit, RA Knights, E Kühn, S Lindenberger, U Plachti, A Pudas, S Roe, JM Skak Madsen, K Solé Padullés, C Sommerer, Y Suri, S Zsoldos, E Fjell, AM Walhovd, KB Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title | Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title_full | Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title_fullStr | Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title_full_unstemmed | Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title_short | Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates |
| title_sort | individual differences in brain aging heterogeneity in cortico hippocampal but not caudate atrophy rates |
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