T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.
Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797096789345566720 |
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| author | Dustin, M Springer, T |
| author_facet | Dustin, M Springer, T |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion. |
| first_indexed | 2024-03-07T04:46:34Z |
| format | Journal article |
| id | oxford-uuid:d381ad41-76a6-413a-a437-688f272184a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:46:34Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:d381ad41-76a6-413a-a437-688f272184a82022-03-27T08:11:33ZT-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d381ad41-76a6-413a-a437-688f272184a8EnglishSymplectic Elements at Oxford1989Dustin, MSpringer, TEffective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion. |
| spellingShingle | Dustin, M Springer, T T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title | T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title_full | T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title_fullStr | T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title_full_unstemmed | T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title_short | T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. |
| title_sort | t cell receptor cross linking transiently stimulates adhesiveness through lfa 1 |
| work_keys_str_mv | AT dustinm tcellreceptorcrosslinkingtransientlystimulatesadhesivenessthroughlfa1 AT springert tcellreceptorcrosslinkingtransientlystimulatesadhesivenessthroughlfa1 |