Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs wit...
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797096802624733184 |
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| author | Thorgeirsson, T Gudbjartsson, D Surakka, I Vink, J Amin, N Geller, F Sulem, P Rafnar, T Esko, T Walter, S Gieger, C Rawal, R Mangino, M Prokopenko, I Mägi, R Keskitalo, K Gudjonsdottir, I Gretarsdottir, S Stefansson, H Thompson, JR Aulchenko, Y Nelis, M Aben, K den Heijer, M Dirksen, A Ashraf, H Soranzo, N Valdes, A Steves, C Uitterlinden, A Hofman, A Tönjes, A Kovacs, P Hottenga, J Willemsen, G Vogelzangs, N Döring, A Dahmen, N Nitz, B Pergadia, M Saez, B De Diego, V Lezcano, V Garcia-Prats, MD Ripatti, S Perola, M Kettunen, J Hartikainen, A Pouta, A Laitinen, J Isohanni, M Huei-Yi, S Allen, M Krestyaninova, M Hall, A Jones, G van Rij, A Mueller, T Dieplinger, B Haltmayer, M Jonsson, S Matthiasson, SE Oskarsson, H Tyrfingsson, T Kiemeney, L Mayordomo, J Lindholt, J Pedersen, J Franklin, W Wolf, H Montgomery, G Heath, A Martin, N Madden, P Giegling, I Rujescu, D Järvelin, MR Salomaa, V Stumvoll, M Spector, T Wichmann, H Metspalu, A Samani, N Penninx, B Oostra, B Boomsma, D Tiemeier, H van Duijn, C Kaprio, J Gulcher, JR McCarthy, M Peltonen, L Thorsteinsdottir, U Stefansson, K |
| author_facet | Thorgeirsson, T Gudbjartsson, D Surakka, I Vink, J Amin, N Geller, F Sulem, P Rafnar, T Esko, T Walter, S Gieger, C Rawal, R Mangino, M Prokopenko, I Mägi, R Keskitalo, K Gudjonsdottir, I Gretarsdottir, S Stefansson, H Thompson, JR Aulchenko, Y Nelis, M Aben, K den Heijer, M Dirksen, A Ashraf, H Soranzo, N Valdes, A Steves, C Uitterlinden, A Hofman, A Tönjes, A Kovacs, P Hottenga, J Willemsen, G Vogelzangs, N Döring, A Dahmen, N Nitz, B Pergadia, M Saez, B De Diego, V Lezcano, V Garcia-Prats, MD Ripatti, S Perola, M Kettunen, J Hartikainen, A Pouta, A Laitinen, J Isohanni, M Huei-Yi, S Allen, M Krestyaninova, M Hall, A Jones, G van Rij, A Mueller, T Dieplinger, B Haltmayer, M Jonsson, S Matthiasson, SE Oskarsson, H Tyrfingsson, T Kiemeney, L Mayordomo, J Lindholt, J Pedersen, J Franklin, W Wolf, H Montgomery, G Heath, A Martin, N Madden, P Giegling, I Rujescu, D Järvelin, MR Salomaa, V Stumvoll, M Spector, T Wichmann, H Metspalu, A Samani, N Penninx, B Oostra, B Boomsma, D Tiemeier, H van Duijn, C Kaprio, J Gulcher, JR McCarthy, M Peltonen, L Thorsteinsdottir, U Stefansson, K |
| author_sort | Thorgeirsson, T |
| collection | OXFORD |
| description | Smoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 represented by rs1051730[A] (effect size = 0.80 CPD, P = 2.4 x 10(-69)), and SNPs at 19q13 and 8p11, represented by rs4105144[C] (effect size = 0.39 CPD, P = 2.2 x 10(-12)) and rs6474412-T (effect size = 0.29 CPD, P = 1.4 x 10(-8)), respectively. Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence. Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006). |
| first_indexed | 2024-03-07T04:46:45Z |
| format | Journal article |
| id | oxford-uuid:d38f66d8-9b92-4389-b5d7-27762b56922f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:46:45Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:d38f66d8-9b92-4389-b5d7-27762b56922f2022-03-27T08:12:29ZSequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d38f66d8-9b92-4389-b5d7-27762b56922fEnglishSymplectic Elements at Oxford2010Thorgeirsson, TGudbjartsson, DSurakka, IVink, JAmin, NGeller, FSulem, PRafnar, TEsko, TWalter, SGieger, CRawal, RMangino, MProkopenko, IMägi, RKeskitalo, KGudjonsdottir, IGretarsdottir, SStefansson, HThompson, JRAulchenko, YNelis, MAben, Kden Heijer, MDirksen, AAshraf, HSoranzo, NValdes, ASteves, CUitterlinden, AHofman, ATönjes, AKovacs, PHottenga, JWillemsen, GVogelzangs, NDöring, ADahmen, NNitz, BPergadia, MSaez, BDe Diego, VLezcano, VGarcia-Prats, MDRipatti, SPerola, MKettunen, JHartikainen, APouta, ALaitinen, JIsohanni, MHuei-Yi, SAllen, MKrestyaninova, MHall, AJones, Gvan Rij, AMueller, TDieplinger, BHaltmayer, MJonsson, SMatthiasson, SEOskarsson, HTyrfingsson, TKiemeney, LMayordomo, JLindholt, JPedersen, JFranklin, WWolf, HMontgomery, GHeath, AMartin, NMadden, PGiegling, IRujescu, DJärvelin, MRSalomaa, VStumvoll, MSpector, TWichmann, HMetspalu, ASamani, NPenninx, BOostra, BBoomsma, DTiemeier, Hvan Duijn, CKaprio, JGulcher, JRMcCarthy, MPeltonen, LThorsteinsdottir, UStefansson, KSmoking is a common risk factor for many diseases. We conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = 31,266) and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium. In a second stage, we tested selected SNPs with in silico replication in the Tobacco and Genetics (TAG) and Glaxo Smith Kline (Ox-GSK) consortia cohorts (n = 45,691 smokers) and assessed some of those in a third sample of European ancestry (n = 9,040). Variants in three genomic regions associated with CPD (P < 5 x 10(-8)), including previously identified SNPs at 15q25 represented by rs1051730[A] (effect size = 0.80 CPD, P = 2.4 x 10(-69)), and SNPs at 19q13 and 8p11, represented by rs4105144[C] (effect size = 0.39 CPD, P = 2.2 x 10(-12)) and rs6474412-T (effect size = 0.29 CPD, P = 1.4 x 10(-8)), respectively. Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence. Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006). |
| spellingShingle | Thorgeirsson, T Gudbjartsson, D Surakka, I Vink, J Amin, N Geller, F Sulem, P Rafnar, T Esko, T Walter, S Gieger, C Rawal, R Mangino, M Prokopenko, I Mägi, R Keskitalo, K Gudjonsdottir, I Gretarsdottir, S Stefansson, H Thompson, JR Aulchenko, Y Nelis, M Aben, K den Heijer, M Dirksen, A Ashraf, H Soranzo, N Valdes, A Steves, C Uitterlinden, A Hofman, A Tönjes, A Kovacs, P Hottenga, J Willemsen, G Vogelzangs, N Döring, A Dahmen, N Nitz, B Pergadia, M Saez, B De Diego, V Lezcano, V Garcia-Prats, MD Ripatti, S Perola, M Kettunen, J Hartikainen, A Pouta, A Laitinen, J Isohanni, M Huei-Yi, S Allen, M Krestyaninova, M Hall, A Jones, G van Rij, A Mueller, T Dieplinger, B Haltmayer, M Jonsson, S Matthiasson, SE Oskarsson, H Tyrfingsson, T Kiemeney, L Mayordomo, J Lindholt, J Pedersen, J Franklin, W Wolf, H Montgomery, G Heath, A Martin, N Madden, P Giegling, I Rujescu, D Järvelin, MR Salomaa, V Stumvoll, M Spector, T Wichmann, H Metspalu, A Samani, N Penninx, B Oostra, B Boomsma, D Tiemeier, H van Duijn, C Kaprio, J Gulcher, JR McCarthy, M Peltonen, L Thorsteinsdottir, U Stefansson, K Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title_full | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title_fullStr | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title_full_unstemmed | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title_short | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. |
| title_sort | sequence variants at chrnb3 chrna6 and cyp2a6 affect smoking behavior |
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