Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim.
Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP was achieved by linking the 4-amino function to the methylene group by o...
Main Authors: | Kuyper, L, Garvey, J, Baccanari, D, Champness, J, Stammers, D, Beddell, C |
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Format: | Journal article |
Language: | English |
Published: |
1996
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