Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
BACKGROUND: We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter r...
Main Authors: | Lessi, F, Beggs, A, de Palo, M, Anti, M, Macarone Palmieri, R, Francesconi, S, Gomes, V, Bevilacqua, G, Tomlinson, I, Segditsas, S |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2010
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