Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.
A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-α-galactosyl ceramide derivat...
| 主要な著者: | , , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2012
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| _version_ | 1826298504388018176 |
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| author | Jervis, P Moulis, M Jukes, J Ghadbane, H Cox, L Cerundolo, V Besra, G |
| author_facet | Jervis, P Moulis, M Jukes, J Ghadbane, H Cox, L Cerundolo, V Besra, G |
| author_sort | Jervis, P |
| collection | OXFORD |
| description | A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. |
| first_indexed | 2024-03-07T04:47:52Z |
| format | Journal article |
| id | oxford-uuid:d3eda892-c7c0-46ad-92d5-eff55c9774ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:47:52Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:d3eda892-c7c0-46ad-92d5-eff55c9774ab2022-03-27T08:14:45ZTowards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d3eda892-c7c0-46ad-92d5-eff55c9774abEnglishSymplectic Elements at Oxford2012Jervis, PMoulis, MJukes, JGhadbane, HCox, LCerundolo, VBesra, GA library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6"-azido-6"-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. |
| spellingShingle | Jervis, P Moulis, M Jukes, J Ghadbane, H Cox, L Cerundolo, V Besra, G Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title | Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title_full | Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title_fullStr | Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title_full_unstemmed | Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title_short | Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. |
| title_sort | towards multivalent cd1d ligands synthesis and biological activity of homodimeric α galactosyl ceramide analogues |
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