Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation.
Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calci...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Lippincott, Williams & Wilkins
2016
|
| _version_ | 1797096895023153152 |
|---|---|
| author | Opstelten, J Leenders, M Dik, V Chan, S van Schaik, F Khaw, K Luben, R Hallmans, G Karling, P Lindgren, S Grip, O Key, T Crowe, F Boeing, H Bergmann, M Overvad, K Palli, D Masala, G Racine, A Carbonnel, F Boutron-Ruault, M Tjønneland, A Olsen, A Andersen, V Kaaks, R Katzke, V Tumino, R Trichopoulou, A Siersema, P Bueno-de-Mesquita, H Hart, A Oldenburg, B |
| author_facet | Opstelten, J Leenders, M Dik, V Chan, S van Schaik, F Khaw, K Luben, R Hallmans, G Karling, P Lindgren, S Grip, O Key, T Crowe, F Boeing, H Bergmann, M Overvad, K Palli, D Masala, G Racine, A Carbonnel, F Boutron-Ruault, M Tjønneland, A Olsen, A Andersen, V Kaaks, R Katzke, V Tumino, R Trichopoulou, A Siersema, P Bueno-de-Mesquita, H Hart, A Oldenburg, B |
| author_sort | Opstelten, J |
| collection | OXFORD |
| description | Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium, and the subsequent development of Crohn's disease (CD) and ulcerative colitis (UC).In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, and cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n = 110) or UC (n = 244) during follow-up were matched with 4 controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking.Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI, 0.32-1.19, p trend = 0.19) and 0.63 (95% CI, 0.28-1.42, p trend = 0.23) for CD, and 0.80 (95% CI, 0.50-1.30, p trend = 0.40) and 0.81 (95% CI, 0.49-1.34, p trend = 0.60) for UC, respectively. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI, 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI, 0.49-1.47).Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect. |
| first_indexed | 2024-03-07T04:47:59Z |
| format | Journal article |
| id | oxford-uuid:d3f628ef-ca31-4f88-8f37-2b2e18bec43d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:47:59Z |
| publishDate | 2016 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:d3f628ef-ca31-4f88-8f37-2b2e18bec43d2022-03-27T08:15:10ZDairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d3f628ef-ca31-4f88-8f37-2b2e18bec43dEnglishSymplectic Elements at OxfordLippincott, Williams & Wilkins2016Opstelten, JLeenders, MDik, VChan, Svan Schaik, FKhaw, KLuben, RHallmans, GKarling, PLindgren, SGrip, OKey, TCrowe, FBoeing, HBergmann, MOvervad, KPalli, DMasala, GRacine, ACarbonnel, FBoutron-Ruault, MTjønneland, AOlsen, AAndersen, VKaaks, RKatzke, VTumino, RTrichopoulou, ASiersema, PBueno-de-Mesquita, HHart, AOldenburg, BDairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium, and the subsequent development of Crohn's disease (CD) and ulcerative colitis (UC).In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, and cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n = 110) or UC (n = 244) during follow-up were matched with 4 controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking.Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI, 0.32-1.19, p trend = 0.19) and 0.63 (95% CI, 0.28-1.42, p trend = 0.23) for CD, and 0.80 (95% CI, 0.50-1.30, p trend = 0.40) and 0.81 (95% CI, 0.49-1.34, p trend = 0.60) for UC, respectively. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI, 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI, 0.49-1.47).Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect. |
| spellingShingle | Opstelten, J Leenders, M Dik, V Chan, S van Schaik, F Khaw, K Luben, R Hallmans, G Karling, P Lindgren, S Grip, O Key, T Crowe, F Boeing, H Bergmann, M Overvad, K Palli, D Masala, G Racine, A Carbonnel, F Boutron-Ruault, M Tjønneland, A Olsen, A Andersen, V Kaaks, R Katzke, V Tumino, R Trichopoulou, A Siersema, P Bueno-de-Mesquita, H Hart, A Oldenburg, B Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title | Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title_full | Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title_fullStr | Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title_full_unstemmed | Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title_short | Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European Prospective Cohort Investigation. |
| title_sort | dairy products dietary calcium and risk of inflammatory bowel disease results from a european prospective cohort investigation |
| work_keys_str_mv | AT opsteltenj dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT leendersm dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT dikv dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT chans dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT vanschaikf dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT khawk dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT lubenr dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT hallmansg dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT karlingp dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT lindgrens dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT gripo dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT keyt dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT crowef dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT boeingh dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT bergmannm dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT overvadk dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT pallid dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT masalag dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT racinea dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT carbonnelf dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT boutronruaultm dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT tjønnelanda dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT olsena dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT andersenv dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT kaaksr dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT katzkev dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT tuminor dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT trichopouloua dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT siersemap dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT buenodemesquitah dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT harta dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation AT oldenburgb dairyproductsdietarycalciumandriskofinflammatoryboweldiseaseresultsfromaeuropeanprospectivecohortinvestigation |