Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.
The EphA4 tyrosine kinase cell surface receptor regulates an array of physiological processes and is the only currently known class A Eph receptor that binds both A and B class ephrins with high affinity. We have solved the crystal structure of the EphA4 ligand binding domain alone and in complex wi...
| Main Authors: | , , , , , , , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
2009
|