Combined optical sizing and acoustical characterization of single freely-floating microbubbles
In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to po...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
AIP Publishing
2016
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| _version_ | 1797096938929127424 |
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| author | Luan, Y Renaud, G Raymond, J Segers, T Lajoinie, G Beurskens, R Mastik, F Kokhuis, T Van Der Steen, A Versluis, M De Jong, N |
| author_facet | Luan, Y Renaud, G Raymond, J Segers, T Lajoinie, G Beurskens, R Mastik, F Kokhuis, T Van Der Steen, A Versluis, M De Jong, N |
| author_sort | Luan, Y |
| collection | OXFORD |
| description | In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a streamline within the confocal region of three ultrasound transducers and a high-resolution microscope objective. Bright-field images of microbubbles passing through the confocal region were captured using a high-speed camera synchronized to the acoustical data acquisition to assess the microbubble response to a 1-MHz ultrasound burst. Nonlinear bubble vibrations were identified at a driving pressure as low as 50 kPa. The results demonstrate good agreement with numerical simulations based on the shell-buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499-3505 (2005)]. The system demonstrates the potential for a high-throughput in vitro characterization of individual microbubbles. |
| first_indexed | 2024-03-07T04:48:37Z |
| format | Journal article |
| id | oxford-uuid:d42f4b61-044e-4530-8637-ef6dc3d34dfd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:48:37Z |
| publishDate | 2016 |
| publisher | AIP Publishing |
| record_format | dspace |
| spelling | oxford-uuid:d42f4b61-044e-4530-8637-ef6dc3d34dfd2022-03-27T08:16:33ZCombined optical sizing and acoustical characterization of single freely-floating microbubblesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d42f4b61-044e-4530-8637-ef6dc3d34dfdEnglishSymplectic Elements at OxfordAIP Publishing2016Luan, YRenaud, GRaymond, JSegers, TLajoinie, GBeurskens, RMastik, FKokhuis, TVan Der Steen, AVersluis, MDe Jong, NIn this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a streamline within the confocal region of three ultrasound transducers and a high-resolution microscope objective. Bright-field images of microbubbles passing through the confocal region were captured using a high-speed camera synchronized to the acoustical data acquisition to assess the microbubble response to a 1-MHz ultrasound burst. Nonlinear bubble vibrations were identified at a driving pressure as low as 50 kPa. The results demonstrate good agreement with numerical simulations based on the shell-buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499-3505 (2005)]. The system demonstrates the potential for a high-throughput in vitro characterization of individual microbubbles. |
| spellingShingle | Luan, Y Renaud, G Raymond, J Segers, T Lajoinie, G Beurskens, R Mastik, F Kokhuis, T Van Der Steen, A Versluis, M De Jong, N Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title | Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title_full | Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title_fullStr | Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title_full_unstemmed | Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title_short | Combined optical sizing and acoustical characterization of single freely-floating microbubbles |
| title_sort | combined optical sizing and acoustical characterization of single freely floating microbubbles |
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