Beta-catenin in the melanocyte lineage.
beta-Catenin is a multifunctional protein involved in cell-cell adhesion, intracellular signalling and gene transcription. It has been implicated in the development of various lineages, including neural crest derivatives. Melanocytes are derived from neural crest cells and beta-catenin is expressed...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797096955544862720 |
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| author | Larue, L Kumasaka, M Goding, C |
| author_facet | Larue, L Kumasaka, M Goding, C |
| author_sort | Larue, L |
| collection | OXFORD |
| description | beta-Catenin is a multifunctional protein involved in cell-cell adhesion, intracellular signalling and gene transcription. It has been implicated in the development of various lineages, including neural crest derivatives. Melanocytes are derived from neural crest cells and beta-catenin is expressed throughout the development of this cell lineage. The multifunctional activity of beta-catenin is directly associated with its participation in multi protein-protein interactions. The cell-cell adhesion function of beta-catenin is mediated by the large cadherin cell adhesion molecule family, the intracellular signalling function by its interaction with GSK3beta, and the gene transcription activity by the four known LEF/TCF DNA binding-proteins. Here, we review the known beta-catenin interacting factors and targets involved in the development and transformation of melanocytes and in particular its role in the expression of the crucial gene of melanocyte development, Mitf. |
| first_indexed | 2024-03-07T04:48:52Z |
| format | Journal article |
| id | oxford-uuid:d441cf7f-9f77-41cf-b2fa-71dbdb2840db |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:48:52Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:d441cf7f-9f77-41cf-b2fa-71dbdb2840db2022-03-27T08:17:13ZBeta-catenin in the melanocyte lineage.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d441cf7f-9f77-41cf-b2fa-71dbdb2840dbEnglishSymplectic Elements at Oxford2003Larue, LKumasaka, MGoding, Cbeta-Catenin is a multifunctional protein involved in cell-cell adhesion, intracellular signalling and gene transcription. It has been implicated in the development of various lineages, including neural crest derivatives. Melanocytes are derived from neural crest cells and beta-catenin is expressed throughout the development of this cell lineage. The multifunctional activity of beta-catenin is directly associated with its participation in multi protein-protein interactions. The cell-cell adhesion function of beta-catenin is mediated by the large cadherin cell adhesion molecule family, the intracellular signalling function by its interaction with GSK3beta, and the gene transcription activity by the four known LEF/TCF DNA binding-proteins. Here, we review the known beta-catenin interacting factors and targets involved in the development and transformation of melanocytes and in particular its role in the expression of the crucial gene of melanocyte development, Mitf. |
| spellingShingle | Larue, L Kumasaka, M Goding, C Beta-catenin in the melanocyte lineage. |
| title | Beta-catenin in the melanocyte lineage. |
| title_full | Beta-catenin in the melanocyte lineage. |
| title_fullStr | Beta-catenin in the melanocyte lineage. |
| title_full_unstemmed | Beta-catenin in the melanocyte lineage. |
| title_short | Beta-catenin in the melanocyte lineage. |
| title_sort | beta catenin in the melanocyte lineage |
| work_keys_str_mv | AT laruel betacatenininthemelanocytelineage AT kumasakam betacatenininthemelanocytelineage AT godingc betacatenininthemelanocytelineage |