Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels
MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV inf...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2019
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| _version_ | 1797096958484021248 |
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| author | Alharbi, N Qasim, I Almasoud, A Aljami, H Alenazi, M Alhafufi, A Aldibasi, O Hashem, A Kasem, S Albrahim, R Aldubaib, M Almansour, A Temperton, N Kupke, A Becker, S Abu-Obaidah, A Alkarar, A Yoon, I Azhar, E Lambe, T Bayoumi, F Aldowerij, A Ibrahim, O Gilbert, S Balkhy, H |
| author_facet | Alharbi, N Qasim, I Almasoud, A Aljami, H Alenazi, M Alhafufi, A Aldibasi, O Hashem, A Kasem, S Albrahim, R Aldubaib, M Almansour, A Temperton, N Kupke, A Becker, S Abu-Obaidah, A Alkarar, A Yoon, I Azhar, E Lambe, T Bayoumi, F Aldowerij, A Ibrahim, O Gilbert, S Balkhy, H |
| author_sort | Alharbi, N |
| collection | OXFORD |
| description | MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels. |
| first_indexed | 2024-03-07T04:48:54Z |
| format | Journal article |
| id | oxford-uuid:d446b49f-01e1-410d-8a4f-603a4e649a7e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:48:54Z |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:d446b49f-01e1-410d-8a4f-603a4e649a7e2022-03-27T08:17:22ZHumoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camelsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d446b49f-01e1-410d-8a4f-603a4e649a7eEnglishSymplectic Elements at OxfordSpringer Nature2019Alharbi, NQasim, IAlmasoud, AAljami, HAlenazi, MAlhafufi, AAldibasi, OHashem, AKasem, SAlbrahim, RAldubaib, MAlmansour, ATemperton, NKupke, ABecker, SAbu-Obaidah, AAlkarar, AYoon, IAzhar, ELambe, TBayoumi, FAldowerij, AIbrahim, OGilbert, SBalkhy, HMERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels. |
| spellingShingle | Alharbi, N Qasim, I Almasoud, A Aljami, H Alenazi, M Alhafufi, A Aldibasi, O Hashem, A Kasem, S Albrahim, R Aldubaib, M Almansour, A Temperton, N Kupke, A Becker, S Abu-Obaidah, A Alkarar, A Yoon, I Azhar, E Lambe, T Bayoumi, F Aldowerij, A Ibrahim, O Gilbert, S Balkhy, H Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title | Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title_full | Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title_fullStr | Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title_full_unstemmed | Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title_short | Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels |
| title_sort | humoral immunogenicity and efficacy of a single dose of chadox1 mers vaccine candidate in dromedary camels |
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