Towards extracellular vesicle based gene therapy for Huntington's disease

Towards extracellular vesicle based gene therapy for Huntington's disease

<p>Huntington's disease (HD) can be regarded as a model neurodegenerative disorder to screen potential genetic based therapeutics and their carriers. It is an autosomal dominant disorder caused by a mutation in a single gene that leads to progressive neurodegeneration caused in part by pr...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखक:	O'Loughlin, A
अन्य लेखक:	Wood, M
स्वरूप:	थीसिस
प्रकाशित:	2016
विषय:	Neurosciences

समान संसाधन

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington's disease mice
द्वारा: Sidong Chen, और अन्य
प्रकाशित: (2021-10-01)

DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
द्वारा: Bhagyashree S. Joshi, और अन्य
प्रकाशित: (2021-11-01)

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System
द्वारा: David R. Graykowski, और अन्य
प्रकाशित: (2020-09-01)

Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis
द्वारा: Ebenezer C. Ikefuama, और अन्य
प्रकाशित: (2025-03-01)

Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
द्वारा: Zhichun Chen, और अन्य
प्रकाशित: (2024-07-01)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
द्वारा: Deanna M. Marchionini, और अन्य
प्रकाशित: (2022-10-01)

Kinesin-2 motors differentially impact biogenesis of extracellular vesicle subpopulations shed from sensory cilia
द्वारा: Michael Clupper, और अन्य
प्रकाशित: (2022-11-01)

Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors
द्वारा: Mohitkumar R. Gangwani, और अन्य
प्रकाशित: (2023-01-01)

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication
द्वारा: Yi-Zhi Wang, और अन्य
प्रकाशित: (2024-02-01)

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
द्वारा: Anna Antoniou, और अन्य
प्रकाशित: (2023-02-01)

Serum amyloid A and mitochondrial DNA in extracellular vesicles are novel markers for detecting traumatic brain injury in a mouse model
द्वारा: Tony Z. Tang, और अन्य
प्रकाशित: (2024-02-01)

Huntington disease alters the actionable information in plasma extracellular vesicles
द्वारा: Andreas Neueder, और अन्य
प्रकाशित: (2024-01-01)

Metabolic and transcriptomic analysis of Huntington’s disease model reveal changes in intracellular glucose levels and related genes
द्वारा: Gepoliano Chaves, और अन्य
प्रकाशित: (2017-08-01)

Investigating the viability of motoric task performance as a clinical biomarker in Huntington’s and Parkinson’s disease
द्वारा: Jayaraj, MS
प्रकाशित: (2014)

Extracellular vesicle-mediated trafficking of molecular cues during human brain development
द्वारा: Andrea Forero, और अन्य
प्रकाशित: (2024-10-01)

A protocol for isolation and culturing of mouse primary postmitotic photoreceptors and isolation of extracellular vesicles
द्वारा: Aikaterini A. Kalargyrou, और अन्य
प्रकाशित: (2024-03-01)

Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice
द्वारा: Oliver K. Fuller, और अन्य
प्रकाशित: (2025-02-01)

Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease
द्वारा: Jia-Hui Chen, और अन्य
प्रकाशित: (2023-12-01)

Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
द्वारा: Linnea S. Ransom, और अन्य
प्रकाशित: (2024-04-01)

Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
द्वारा: Rachel H. Mansky, और अन्य
प्रकाशित: (2023-03-01)

Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo
द्वारा: Victor Bodart-Santos, और अन्य
प्रकाशित: (2024-12-01)

Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
द्वारा: D.J. Vidyadhara, और अन्य
प्रकाशित: (2023-03-01)

Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease
द्वारा: Marina Herrero‐Lorenzo, और अन्य
प्रकाशित: (2024-10-01)

Early molecular and behavioural changes associated with BDNF-TrkB signalling: insights into Huntington's disease
द्वारा: Malik, MY
प्रकाशित: (2023)

AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease
द्वारा: Xin Chen, और अन्य
प्रकाशित: (2022-03-01)

VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion
द्वारा: Xiaohua Dong, और अन्य
प्रकाशित: (2022-04-01)

Gene therapy for Huntington's disease
द्वारा: Shilpa Ramaswamy, और अन्य
प्रकाशित: (2012-11-01)

Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey
द्वारा: Shiran Katabi, और अन्य
प्रकाशित: (2024-06-01)

Functional delivery of lipid-conjugated siRNA by extracellular vesicles
द्वारा: O'Loughlin, A, और अन्य
प्रकाशित: (2017)

N-glycoproteomics of brain synapses and synaptic vesicles
द्वारा: Mazdak M. Bradberry, और अन्य
प्रकाशित: (2023-04-01)

Neural extracellular matrix regulates visual sensory motor integration
द्वारा: Jacqueline Reinhard, और अन्य
प्रकाशित: (2024-02-01)

Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle
द्वारा: Maggie S. Matern, और अन्य
प्रकाशित: (2023-06-01)

Nanoscale and functional heterogeneity of the hippocampal extracellular space
द्वारा: Diego Grassi, और अन्य
प्रकाशित: (2023-05-01)

Exosomes and the emerging field of exosome-based gene therapy.
द्वारा: O'Loughlin, A, और अन्य
प्रकाशित: (2012)

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses
द्वारा: Sang-Ho Song, और अन्य
प्रकाशित: (2023-08-01)

Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight
द्वारा: Ellen T. Koch, और अन्य
प्रकाशित: (2024-05-01)

The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System
द्वारा: Yuanning Guo, और अन्य
प्रकाशित: (2022-04-01)

Extracellular Vesicles in Joint Disease and Therapy
द्वारा: Janneke Boere, और अन्य
प्रकाशित: (2018-11-01)

Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
द्वारा: Júlia Solana-Balaguer, और अन्य
प्रकाशित: (2024-06-01)

CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis
द्वारा: Fumiaki Oka, और अन्य
प्रकाशित: (2022-04-01)