Towards extracellular vesicle based gene therapy for Huntington's disease

Towards extracellular vesicle based gene therapy for Huntington's disease

<p>Huntington's disease (HD) can be regarded as a model neurodegenerative disorder to screen potential genetic based therapeutics and their carriers. It is an autosomal dominant disorder caused by a mutation in a single gene that leads to progressive neurodegeneration caused in part by pr...

Bibliográfalaš dieđut
Váldodahkki:	O'Loughlin, A
Eará dahkkit:	Wood, M
Materiálatiipa:	Oahppočájánas
Almmustuhtton:	2016
Fáttát:	Neurosciences

Geahča maid

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington's disease mice
Dahkki: Sidong Chen, et al.
Almmustuhtton: (2021-10-01)

DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
Dahkki: Bhagyashree S. Joshi, et al.
Almmustuhtton: (2021-11-01)

The Dichotomous Role of Extracellular Vesicles in the Central Nervous System
Dahkki: David R. Graykowski, et al.
Almmustuhtton: (2020-09-01)

Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis
Dahkki: Ebenezer C. Ikefuama, et al.
Almmustuhtton: (2025-03-01)

Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
Dahkki: Zhichun Chen, et al.
Almmustuhtton: (2024-07-01)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
Dahkki: Deanna M. Marchionini, et al.
Almmustuhtton: (2022-10-01)

Kinesin-2 motors differentially impact biogenesis of extracellular vesicle subpopulations shed from sensory cilia
Dahkki: Michael Clupper, et al.
Almmustuhtton: (2022-11-01)

Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors
Dahkki: Mohitkumar R. Gangwani, et al.
Almmustuhtton: (2023-01-01)

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication
Dahkki: Yi-Zhi Wang, et al.
Almmustuhtton: (2024-02-01)

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
Dahkki: Anna Antoniou, et al.
Almmustuhtton: (2023-02-01)

Serum amyloid A and mitochondrial DNA in extracellular vesicles are novel markers for detecting traumatic brain injury in a mouse model
Dahkki: Tony Z. Tang, et al.
Almmustuhtton: (2024-02-01)

Huntington disease alters the actionable information in plasma extracellular vesicles
Dahkki: Andreas Neueder, et al.
Almmustuhtton: (2024-01-01)

Metabolic and transcriptomic analysis of Huntington’s disease model reveal changes in intracellular glucose levels and related genes
Dahkki: Gepoliano Chaves, et al.
Almmustuhtton: (2017-08-01)

Investigating the viability of motoric task performance as a clinical biomarker in Huntington’s and Parkinson’s disease
Dahkki: Jayaraj, MS
Almmustuhtton: (2014)

Extracellular vesicle-mediated trafficking of molecular cues during human brain development
Dahkki: Andrea Forero, et al.
Almmustuhtton: (2024-10-01)

A protocol for isolation and culturing of mouse primary postmitotic photoreceptors and isolation of extracellular vesicles
Dahkki: Aikaterini A. Kalargyrou, et al.
Almmustuhtton: (2024-03-01)

Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice
Dahkki: Oliver K. Fuller, et al.
Almmustuhtton: (2025-02-01)

Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease
Dahkki: Jia-Hui Chen, et al.
Almmustuhtton: (2023-12-01)

Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
Dahkki: Linnea S. Ransom, et al.
Almmustuhtton: (2024-04-01)

Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
Dahkki: Rachel H. Mansky, et al.
Almmustuhtton: (2023-03-01)

Selenoprotein P is a target for regulating extracellular vesicle biogenesis and secretion from activated microglia in vivo
Dahkki: Victor Bodart-Santos, et al.
Almmustuhtton: (2024-12-01)

Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
Dahkki: D.J. Vidyadhara, et al.
Almmustuhtton: (2023-03-01)

Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease
Dahkki: Marina Herrero‐Lorenzo, et al.
Almmustuhtton: (2024-10-01)

Early molecular and behavioural changes associated with BDNF-TrkB signalling: insights into Huntington's disease
Dahkki: Malik, MY
Almmustuhtton: (2023)

AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease
Dahkki: Xin Chen, et al.
Almmustuhtton: (2022-03-01)

VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion
Dahkki: Xiaohua Dong, et al.
Almmustuhtton: (2022-04-01)

Gene therapy for Huntington's disease
Dahkki: Shilpa Ramaswamy, et al.
Almmustuhtton: (2012-11-01)

Protocol for extracellular recordings in the external globus pallidus of the behaving/awake monkey
Dahkki: Shiran Katabi, et al.
Almmustuhtton: (2024-06-01)

Functional delivery of lipid-conjugated siRNA by extracellular vesicles
Dahkki: O'Loughlin, A, et al.
Almmustuhtton: (2017)

N-glycoproteomics of brain synapses and synaptic vesicles
Dahkki: Mazdak M. Bradberry, et al.
Almmustuhtton: (2023-04-01)

Neural extracellular matrix regulates visual sensory motor integration
Dahkki: Jacqueline Reinhard, et al.
Almmustuhtton: (2024-02-01)

Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle
Dahkki: Maggie S. Matern, et al.
Almmustuhtton: (2023-06-01)

Nanoscale and functional heterogeneity of the hippocampal extracellular space
Dahkki: Diego Grassi, et al.
Almmustuhtton: (2023-05-01)

Exosomes and the emerging field of exosome-based gene therapy.
Dahkki: O'Loughlin, A, et al.
Almmustuhtton: (2012)

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses
Dahkki: Sang-Ho Song, et al.
Almmustuhtton: (2023-08-01)

Deep behavioural phenotyping of the Q175 Huntington disease mouse model: effects of age, sex, and weight
Dahkki: Ellen T. Koch, et al.
Almmustuhtton: (2024-05-01)

The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System
Dahkki: Yuanning Guo, et al.
Almmustuhtton: (2022-04-01)

Extracellular Vesicles in Joint Disease and Therapy
Dahkki: Janneke Boere, et al.
Almmustuhtton: (2018-11-01)

Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease
Dahkki: Júlia Solana-Balaguer, et al.
Almmustuhtton: (2024-06-01)

CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis
Dahkki: Fumiaki Oka, et al.
Almmustuhtton: (2022-04-01)