Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

The mechanisms underlying hematopoietic lineage decisions remain disputed. Lineage affiliated transcription factors (TFs) with the capacity for lineage reprogramming, positive auto-regulation and mutual inhibition have been described to be expressed in uncommitted cell populations. This has led to t...

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Bibliografische gegevens
Hoofdauteurs: Hoppe, P, Schwarzfischer, M, Loeffler, D, Kokkaliaris, K, Hilsenbeck, O, Moritz, N, Endele, M, Filipczyk, A, Gambardella, A, Ahmed, N, Etzrodt, M, Coutu, D, Rieger, M, Marr, C, Strasser, M, Schauberger, B, Burtscher, I, Ermakova, O, Bürger, A, Lickert, H, Nerlov, C, Theis, F, Schroeder, T
Formaat: Journal article
Taal:English
Gepubliceerd in: Nature Publishing Group 2016

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