Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey
<strong>Objective<br></strong> We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. <br><strong> Methods<br></stron...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2022
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| _version_ | 1797107427780329472 |
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| author | Buchanan, J Hill, M Vass, CM Hammond, J Riedijk, S Klapwijk, JE Harding, E Lou, S Vogel, I Hui, L Ingvoldstad-Malmgren, C Soller, MJ Ormond, KE Choolani, M Zheng, Q Chitty, LS Lewis, C |
| author_facet | Buchanan, J Hill, M Vass, CM Hammond, J Riedijk, S Klapwijk, JE Harding, E Lou, S Vogel, I Hui, L Ingvoldstad-Malmgren, C Soller, MJ Ormond, KE Choolani, M Zheng, Q Chitty, LS Lewis, C |
| author_sort | Buchanan, J |
| collection | OXFORD |
| description | <strong>Objective<br></strong>
We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries.
<br><strong>
Methods<br></strong>
Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis.
<br><strong>
Results<br></strong>
Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs.
<br><strong>
Conclusion<br></strong>
Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable. |
| first_indexed | 2024-03-07T07:15:55Z |
| format | Journal article |
| id | oxford-uuid:d4891202-f54a-4a01-a575-5b413a95b4f8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:15:55Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:d4891202-f54a-4a01-a575-5b413a95b4f82022-08-09T12:03:40ZFactors that impact on women's decision-making around prenatal genomic tests: an international discrete choice surveyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d4891202-f54a-4a01-a575-5b413a95b4f8EnglishSymplectic ElementsWiley2022Buchanan, JHill, MVass, CMHammond, JRiedijk, SKlapwijk, JEHarding, ELou, SVogel, IHui, LIngvoldstad-Malmgren, CSoller, MJOrmond, KEChoolani, MZheng, QChitty, LSLewis, C<strong>Objective<br></strong> We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. <br><strong> Methods<br></strong> Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. <br><strong> Results<br></strong> Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. <br><strong> Conclusion<br></strong> Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable. |
| spellingShingle | Buchanan, J Hill, M Vass, CM Hammond, J Riedijk, S Klapwijk, JE Harding, E Lou, S Vogel, I Hui, L Ingvoldstad-Malmgren, C Soller, MJ Ormond, KE Choolani, M Zheng, Q Chitty, LS Lewis, C Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title | Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title_full | Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title_fullStr | Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title_full_unstemmed | Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title_short | Factors that impact on women's decision-making around prenatal genomic tests: an international discrete choice survey |
| title_sort | factors that impact on women s decision making around prenatal genomic tests an international discrete choice survey |
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