| Summary: | <p>Considering the ample evidence of involvement of the glutamate system in the pathophysiology of depression, pre-clinical and clinical studies have been conducted to assess the antidepressant efficacy of glutamate inhibition, and glutamate receptor modulators in particular. This review focuses on the use of glutamate receptor modulators in unipolar depression.</p> <br/> <p>This review is an abridged version of a Cochrane review previously published in the Cochrane Database of Systematic Reviews, 2015, Sept 23, Issue 9: CD011612.</p>
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