From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand.
The binding of CD40 ligand (CD40L) to CD40 stimulates inflammatory processes including the release of proinflammatory cytokines and the expression of adhesion molecules implying a role in atherosclerosis. Patients exhibiting hypercholesterolemia, unstable angina, or acute myocardial infarction prese...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826298639867183104 |
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| author | Tousoulis, D Androulakis, E Papageorgiou, N Briasoulis, A Siasos, G Antoniades, C Stefanadis, C |
| author_facet | Tousoulis, D Androulakis, E Papageorgiou, N Briasoulis, A Siasos, G Antoniades, C Stefanadis, C |
| author_sort | Tousoulis, D |
| collection | OXFORD |
| description | The binding of CD40 ligand (CD40L) to CD40 stimulates inflammatory processes including the release of proinflammatory cytokines and the expression of adhesion molecules implying a role in atherosclerosis. Patients exhibiting hypercholesterolemia, unstable angina, or acute myocardial infarction present with increased CD40L levels. Novel data suggest that elevated soluble CD40L levels not only represent a risk factor for cardiovascular disease but also predict future adverse events, especially in patients with acute coronary syndromes (ACS). Examination of the potential role of the genetic variability on CD40/CD40L genes in ACS, as regards the regulation of CD40L, appears to be of great interest. Moreover, several therapeutic approaches such as statins, antihypertensive agents, and antiplatelet agents have been suggested as potential modulators of CD40L levels anticipating a positive impact on the outcomes of patients with ACS. Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future. |
| first_indexed | 2024-03-07T04:49:54Z |
| format | Journal article |
| id | oxford-uuid:d497d0ac-9318-4872-8238-f83a1e27b22c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:49:54Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:d497d0ac-9318-4872-8238-f83a1e27b22c2022-03-27T08:19:47ZFrom atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d497d0ac-9318-4872-8238-f83a1e27b22cEnglishSymplectic Elements at Oxford2010Tousoulis, DAndroulakis, EPapageorgiou, NBriasoulis, ASiasos, GAntoniades, CStefanadis, CThe binding of CD40 ligand (CD40L) to CD40 stimulates inflammatory processes including the release of proinflammatory cytokines and the expression of adhesion molecules implying a role in atherosclerosis. Patients exhibiting hypercholesterolemia, unstable angina, or acute myocardial infarction present with increased CD40L levels. Novel data suggest that elevated soluble CD40L levels not only represent a risk factor for cardiovascular disease but also predict future adverse events, especially in patients with acute coronary syndromes (ACS). Examination of the potential role of the genetic variability on CD40/CD40L genes in ACS, as regards the regulation of CD40L, appears to be of great interest. Moreover, several therapeutic approaches such as statins, antihypertensive agents, and antiplatelet agents have been suggested as potential modulators of CD40L levels anticipating a positive impact on the outcomes of patients with ACS. Whether specific agents target the CD40/CD40L system as well as its pathogenic role in ACS remains to be elucidated by large-scale studies in the future. |
| spellingShingle | Tousoulis, D Androulakis, E Papageorgiou, N Briasoulis, A Siasos, G Antoniades, C Stefanadis, C From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title | From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title_full | From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title_fullStr | From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title_full_unstemmed | From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title_short | From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand. |
| title_sort | from atherosclerosis to acute coronary syndromes the role of soluble cd40 ligand |
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