Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these...

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Bibliographic Details
Main Authors:	Baran-Gale, J, Morgan, MD, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, ME, Handel, AE, Maynard, A, Chen, S, Green, F, Sit, RV, Neff, NF, Darmanis, S, Tan, W, May, AP, Marioni, JC, Ponting, CP, Hollander, G
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2020

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