Rheumatological manifestations in patients with melioidosis.
Melioidosis, an infection caused by the bacterium Burkholderia pseudomallei, has a wide range of clinical manifestations. Here, we describe rheumatological melioidosis (involving one or more of joint, bone or muscle), and compare features and outcome with patients without rheumatological involvement...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826298698622042112 |
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| author | Teparrakkul, P Tsai, J Chierakul, W Gerstenmaier, J Wacharaprechasgu, T Piyaphanee, W Limmathurotsakul, D Chaowagul, W Day, N Peacock, S |
| author_facet | Teparrakkul, P Tsai, J Chierakul, W Gerstenmaier, J Wacharaprechasgu, T Piyaphanee, W Limmathurotsakul, D Chaowagul, W Day, N Peacock, S |
| author_sort | Teparrakkul, P |
| collection | OXFORD |
| description | Melioidosis, an infection caused by the bacterium Burkholderia pseudomallei, has a wide range of clinical manifestations. Here, we describe rheumatological melioidosis (involving one or more of joint, bone or muscle), and compare features and outcome with patients without rheumatological involvement. A retrospective study of patients with culture-confirmed melioidosis admitted to Sappasithiprasong Hospital, Ubon Ratchathani during 2002 and 2005 identified 679 patients with melioidosis, of whom 98 (14.4%) had rheumatological melioidosis involving joint (n=52), bone (n = 5), or muscle (n = 12), or a combination of these (n=29). Females were over-represented in the rheumatological group, and diabetes and thalassemia were independent risk factors for rheumatological involvement (OR; 2.49 and 9.56, respectively). Patients with rheumatological involvement had a more chronic course, as reflected by a longer fever clearance time (13 vs 7 days, p = 0.06) and hospitalization (22 vs 14 days, p < 0.001), but lower mortality (28% vs 44%, p = 0.005). Patients with signs and symptoms of septic arthritis for longer than 2 weeks were more likely to have extensive infection of adjacent bone and muscle, particularly in diabetic patients. Surgical intervention was associated with a survival benefit, bur not a shortening of the course of infection. |
| first_indexed | 2024-03-07T04:50:48Z |
| format | Journal article |
| id | oxford-uuid:d4e2a4fd-a681-45ae-87a9-a6e89e76390a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:50:48Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:d4e2a4fd-a681-45ae-87a9-a6e89e76390a2022-03-27T08:22:01ZRheumatological manifestations in patients with melioidosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d4e2a4fd-a681-45ae-87a9-a6e89e76390aEnglishSymplectic Elements at Oxford2008Teparrakkul, PTsai, JChierakul, WGerstenmaier, JWacharaprechasgu, TPiyaphanee, WLimmathurotsakul, DChaowagul, WDay, NPeacock, SMelioidosis, an infection caused by the bacterium Burkholderia pseudomallei, has a wide range of clinical manifestations. Here, we describe rheumatological melioidosis (involving one or more of joint, bone or muscle), and compare features and outcome with patients without rheumatological involvement. A retrospective study of patients with culture-confirmed melioidosis admitted to Sappasithiprasong Hospital, Ubon Ratchathani during 2002 and 2005 identified 679 patients with melioidosis, of whom 98 (14.4%) had rheumatological melioidosis involving joint (n=52), bone (n = 5), or muscle (n = 12), or a combination of these (n=29). Females were over-represented in the rheumatological group, and diabetes and thalassemia were independent risk factors for rheumatological involvement (OR; 2.49 and 9.56, respectively). Patients with rheumatological involvement had a more chronic course, as reflected by a longer fever clearance time (13 vs 7 days, p = 0.06) and hospitalization (22 vs 14 days, p < 0.001), but lower mortality (28% vs 44%, p = 0.005). Patients with signs and symptoms of septic arthritis for longer than 2 weeks were more likely to have extensive infection of adjacent bone and muscle, particularly in diabetic patients. Surgical intervention was associated with a survival benefit, bur not a shortening of the course of infection. |
| spellingShingle | Teparrakkul, P Tsai, J Chierakul, W Gerstenmaier, J Wacharaprechasgu, T Piyaphanee, W Limmathurotsakul, D Chaowagul, W Day, N Peacock, S Rheumatological manifestations in patients with melioidosis. |
| title | Rheumatological manifestations in patients with melioidosis. |
| title_full | Rheumatological manifestations in patients with melioidosis. |
| title_fullStr | Rheumatological manifestations in patients with melioidosis. |
| title_full_unstemmed | Rheumatological manifestations in patients with melioidosis. |
| title_short | Rheumatological manifestations in patients with melioidosis. |
| title_sort | rheumatological manifestations in patients with melioidosis |
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