Iridium-catalyzed reductive Strecker reaction for late-stage amide and lactam cyanation
A new iridium-catalyzed reductive Strecker reaction for the direct and efficient formation of α-amino nitrile products from a broad range of (hetero)aromatic and aliphatic tertiary amides, and N-alkyl lactams is reported. The protocol exploits the mild and highly chemoselective reduction of the amid...
| Main Authors: | , , , , |
|---|---|
| Formato: | Journal article |
| Publicado em: |
Wiley
2017
|