Iridium-catalyzed reductive Strecker reaction for late-stage amide and lactam cyanation

Iridium-catalyzed reductive Strecker reaction for late-stage amide and lactam cyanation

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A new iridium-catalyzed reductive Strecker reaction for the direct and efficient formation of α-amino nitrile products from a broad range of (hetero)aromatic and aliphatic tertiary amides, and N-alkyl lactams is reported. The protocol exploits the mild and highly chemoselective reduction of the amid...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	de Arriba, A, Lenci, E, Sonawane, M, Formery, O, Dixon, D
Fformat:	Journal article
Cyhoeddwyd:	Wiley 2017

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