Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection.
BACKGROUND: The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS: We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection...
| Päätekijät: | , , , , , , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Public Library of Science
2010
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| _version_ | 1826298726240485376 |
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| author | Denney, L Aitken, C Li, C Wilson-Davies, E Kok, W Clelland, C Rooney, K Young, D Dong, T McMichael, A Carman, W Ho, L |
| author_facet | Denney, L Aitken, C Li, C Wilson-Davies, E Kok, W Clelland, C Rooney, K Young, D Dong, T McMichael, A Carman, W Ho, L |
| author_sort | Denney, L |
| collection | OXFORD |
| description | BACKGROUND: The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS: We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients. CONCLUSION/SIGNIFICANCE: Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype. |
| first_indexed | 2024-03-07T04:51:13Z |
| format | Journal article |
| id | oxford-uuid:d505ecc2-cd9e-47d6-8ebb-2e9a852ffef4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:51:13Z |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:d505ecc2-cd9e-47d6-8ebb-2e9a852ffef42022-03-27T08:23:00ZReduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d505ecc2-cd9e-47d6-8ebb-2e9a852ffef4EnglishSymplectic Elements at OxfordPublic Library of Science2010Denney, LAitken, CLi, CWilson-Davies, EKok, WClelland, CRooney, KYoung, DDong, TMcMichael, ACarman, WHo, LBACKGROUND: The cause of severe disease in some patients infected with pandemic influenza A virus is unclear. METHODOLOGY/PRINCIPAL FINDINGS: We present the cellular immunology profile in the blood, and detailed clinical (and post-mortem) findings of three patients with rapidly progressive infection, including a pregnant patient who died. The striking finding is of reduction in natural killer (NK) cells but preservation of activated effector CD8 T lymphocytes; with viraemia in the patient who had no NK cells. Comparison with control groups suggests that the reduction of NK cells is unique to these severely ill patients. CONCLUSION/SIGNIFICANCE: Our report shows markedly reduced NK cells in the three patients that we sampled and raises the hypothesis that NK may have a more significant role than T lymphocytes in controlling viral burden when the host is confronted with a new influenza A virus subtype. |
| spellingShingle | Denney, L Aitken, C Li, C Wilson-Davies, E Kok, W Clelland, C Rooney, K Young, D Dong, T McMichael, A Carman, W Ho, L Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title | Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title_full | Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title_fullStr | Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title_full_unstemmed | Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title_short | Reduction of natural killer but not effector CD8 T lymphocytes in three consecutive cases of severe/lethal H1N1/09 influenza A virus infection. |
| title_sort | reduction of natural killer but not effector cd8 t lymphocytes in three consecutive cases of severe lethal h1n1 09 influenza a virus infection |
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